Evolutionarily conserved intercellular signaling pathways regulate embryonic development and adult tissue homeostasis in metazoans. The precise control of the state and amplitude of signaling pathways is achieved in part through the kinaseand phosphatase-mediated reversible phosphorylation of proteins. In this study, we performed a genome-wide in vivo RNAi screen for kinases and phosphatases th...

Hedgehog (Hh) signaling controls embryonic development and adult tissue homeostasis through the G protein coupled receptor (GPCR)-family protein Smoothened (Smo). Upon stimulation, Smo accumulates on the cell surface in Drosophila or primary cilia in vertebrates, which is thought to be essential for its activation and function, but the underlying mechanisms remain poorly understood. Here we sho...

positions of each vertical projections of long horizontal We have developed a new real-time range-finding edges as particular characteristics of vehicles in front. system based on vertical stereo vision for measuring the distance to vehicles in front. In the system, stereo images are inputted from vertical cameras which are placed in the periphery of the windshield. However, the placement cause...

Since ageing is a universal human feature, it is not surprising that, from the Babylonian epic of Gilgamesh to Ponce de Leon seeking the "Fountain of Youth," countless people have dreamed of finding a way to avoid ageing, to no avail. Yet the search continues. In this review, we present one of the latest candidates: the enzyme telomerase, capable of elongating the tips of chromosomes, the telom...

Bireyin davranışları farklı güdülerle açıklanabilir. İnsanı eyleme geçiren kararlar, gündelik yaşamın bir parçasıdır. Öte yandan alınan rasyonel bireyin seçim kısıtıyla çerçevelenemeyecek kadar kompleks ve dinamiklerle ilintilidir. duygularından değerlerinden soyutlayarak tek tipleştiren rasyonalite kişisel çıkar varsayımları, davranış güdülerdeki bireysel farklılıkları göz ardı etmektedir. Bu ...