BACKGROUND The WASP/SCAR family of adaptor proteins coordinates actin reorganization by coupling different signaling molecules, including Rho-family GTPases, to the activation of the Arp2/3 complex. WASP binds directly to Cdc42 through its GTPase binding domain (GBD), but SCAR does not contain a GBD, and no direct binding has been found. However, SCAR has recently been found to copurify with fo...

BACKGROUND Hypertrophic scar following a burn is caused by the excessive deposit of collagen resulting in an exaggerated wound healing response. The burn patient complains of pain and itching over the scar, which can give rise to cosmetic and functional problems. OBJECTIVE The aim of this study was to investigate the clinical and histological correlation of a hypertrophic burn scar for itchin...

BACKGROUND Hypertrophic scar is one of the most common complications and often causes the disfigurement or deformity in burn or trauma patients. Therapeutic methods on hypertrophic scar treatment have limitations due to the poor understanding of mechanisms of hypertrophic scar formation. To throw light on the molecular mechanism of hypertrophic scar formation will definitely improve the outcome...

The COVID-19 pandemic has instigated tremendous human and economic hardship around the world. Using meta-literature time series analysis, we conduct both synthesis empirical analysis to investigate particularly perspectives of across several financial systems: (a) Asian market, (b) European (c) American market (d) Gulf Cooperation Council (GCC) Middle East North Africa’s (MENA) market. critical...