background: primary focal segmental glomerulosclerosis (fsgs) is defined by the presence of proteinuria, often in nephrotic range and pathologically by segmental scars (ss). the aim of this study is to identify the possible predictors of complete remission or progression to chronic kidney disease in iranian adults with primary focal segmental glomerulosclerosis. methods: in this historical coho...

BACKGROUND Previous studies have shown that viable myocardium predicts recovery of left ventricular (LV) dysfunction after revascularization. Our aim was to evaluate the prognostic value of myocardial scar assessed by late gadolinium-enhanced cardiovascular magnetic resonance imaging (LGE-CMR) on functional recovery in patients undergoing coronary artery bypass grafting (CABG). METHODS From N...

linear and cord-like burn scar contractures are commonly treated by severing the scar in a transverse direction and skin grafting or performing z-plasties. however, skin grafts may result in suboptimal take and contract gradually and the z-plasty requires undermining flaps in scarred skin which may lead to the distal tip necrosis. in this article the authors present their experience with multip...

Background Global left ventricular (LV) remodeling after myocardial infarction frequently occurs. Late Gadolinium Enhancement (LGE) CMR allows imaging of focal myocardial scar with areas remote from scar having no hyperenhancement. Myocardial T1 mapping allows quantification of interstitial fibrosis and may be a surrogate for LV remodeling. We sought to determine if there were T1 abnormalities ...

BACKGROUND The aim of the study was to perform a feature tracking analysis on cine magnetic resonance (MR) images to elucidate if functional measurements of the motion of the left ventricular wall may detect scar defined with gadolinium enhanced MR.Myocardial contraction can be measured in terms of the velocity, displacement and local deformation (strain) of a particular myocardial segment. Con...

Purpose. Early postoperative fractional laser treatment has been used to reduce scarring in many institutions, but the most effective energy parameters have not yet been established. This study sought to determine effective parameters in the treatment of facial laceration scars. Methods. From September 2012 to September 2013, 57 patients were enrolled according to the study. To compare the low ...

BACKGROUND We hypothesised that myocardial deformation determined with magnetic resonance imaging (MRI) will detect myocardial scar. METHODS Displacement Encoding with Stimulated Echoes (DENSE) was used to calculate left ventricular strain in 125 patients (29 women and 96 men) with suspected coronary artery disease. The patients also underwent cine imaging and late gadolinium enhancement. 57 ...

Pharmacovigilance presents many challenges, particularly when managing unpredictable, rare conditions, eg, severe cutaneous adverse reactions (SCARs). Such rare events are often only detected from spontaneous reports, which present their own limitations, particularly during a prolonged global launch schedule. GlaxoSmithKline's routine pharmacovigilance includes regular reviews of global adverse...

Cardiac resynchronization therapy (CRT) is an established treatment for patients with symptomatic heart failure, severely impaired left ventricular (LV) systolic dysfunction and a wide (> 120 ms) complex. As with any other treatment, the response to CRT is variable. The degree of pre-implant mechanical dyssynchrony, scar burden and scar localization to the vicinity of the LV pacing stimulus are...

The "Quantitative Global Scarring Grading System for Postacne Scarring" was developed in English for acne scar grading, based on the number and severity of each type of scar. The aims of this study were to translate this scale into Brazilian Portuguese and verify its reliability and validity. The study followed five steps: Translation, Expert Panel, Back Translation, Approval of authors and Val...