نتایج جستجو برای: gm c

تعداد نتایج: 1073894  

ژورنال: :پژوهش های آسیب شناسی زیستی 0
mehdi mahdavi ph.d. student, department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran massoumeh ebtekar associated professor, department of immunology, faculty of medical sciences, tarbiat modares university, tehran, iran kayhan azadmanesh assistant professor, department of virology, pasteur institute of iran, tehran, iran fereidoun mahboudi associated professor, department of biotechnology, pasteur institute of iran, tehran, iran hamidreza khorram khorshid associated professor, genetics research center, university of social welfare and rehabilitation sciences, tehran, iran fatemeh rahbarizadeh assistant professor, department of biotechnology, faculty of medical sciences, tarbiat modares university, tehran, iran adel mohammadzadeh

هدف: بیماری ایدز امروزه به‏عنوان یک مشکل جهانی مطرح است و تلاش فراوانی برای ساخت واکسن مؤثر ضد بیماری ایدز صورت گرفته اما بی‏نتیجه مانده است. dna واکسن‏ها از جمله واکسن‏های نسل جدید است که می‏تواند سیستم ایمنی را به‏خوبی تحریک نمایند با وجود این، یافته‏های اخیر نمایانگر ایمن‏زایی ضعیف این دسته از واکسن‏ها است و اعتقاد بر اینست که این دسته از واکسن‏ها نیاز به عواملی چون ادجوانت‏ها دارد تا ایمنی‏...

Journal: :Blood 1991
R A Briddell E Bruno R J Cooper J E Brandt R Hoffman

An evaluation of the effects of a recombinant, soluble form of the c-kit ligand alone and in combination with either granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3) on the regulation of human megakaryocytopoiesis was performed using a serum-depleted clonal assay system and a long-term bone marrow culture system. The effects of the c-kit ligand on the primitive ...

Journal: :Blood 1994
Y Sonoda H Sakabe Y Ohmisono S Tanimukai S Yokota S Nakagawa S C Clark T Abe

We studied the synergistic effects of stem cell factor (SCF) and other burst-promoting activities (BPAs) such as interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), or IL-9 on proliferation of human peripheral blood-derived highly purified progenitors. SCF, IL-3, GM-CSF, and IL-9 showed significant BPA when CD34+HLA-DR+ cells were used as the target population. IL-3...

Journal: :Journal of neurology, neurosurgery, and psychiatry 2010
Elisa Scola Marco Bozzali Federica Agosta Giuseppe Magnani Massimo Franceschi Maria Pia Sormani Mara Cercignani Elisabetta Pagani Monica Falautano Massimo Filippi Andrea Falini

OBJECTIVE The authors assessed whether brain changes detected by diffusion tensor (DT) MRI can improve the understanding of structural damage in Alzheimer's disease (AD) and are associated with different risks of conversion to AD in amnestic mild cognitive impairment (aMCI). METHODS Twenty-one aMCI patients, 21 AD patients and 20 healthy subjects underwent conventional and DT MRI at baseline....

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تهران 1379

هدف از انجام این مطالعه بررسی چگونگی اثر ‏‎tgf-b2‎‏ بر بیان ژن ‏‎gm-csf‎‏ انسانی می باشد. ‏‎(gm-csf) granulocyte- macrophage colony stimulating factor ‎‏ قادر به تحریک پدیده تمایز در سلولهای مادری خونساز بوده و فعالیت سلولهای بالغ خونی را تحت تاثیر قرار می دهد. از این جهت همیشه بعنوان یک عامل مهم در پدیده خونسازی مورد توجه بوده است. سلولهای 5637 بدلیل افزایش نیمه عمر رونوشتهای ‏‎(mrna)‎‏ و بیان...

Majid Motovali-Bashi, Tayyebeh Ghasemi,

Background: &beta-thalassemia is the most common monogenic disorder in human. The (CT) polymorphism at -158 upstream region of the &gammaG-globin gene and pharmacological factors such as hydroxyurea have been reported to influence &gamma-globin gene expression and the severity of clinical symptoms of &beta-thalassemia. Methods: In the present study, 51 &beta-thalassemia intermediate patients w...

Journal: :Blood 1984
J H Fitchen C Russo S Ferrone

A complement (C)-dependent antiglobulin assay was utilized to determine the reactivity of non-C-fixing monoclonal antibodies (MoAb) with human granulocyte-macrophage progenitor cells (CFU-GM). The variables of the assay were analyzed with non-C-fixing MoAb against Ia antigens, including CR11-462, which recognizes the same (or spatially close) determinant identified by the C-fixing anti-Ia MoAb ...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014
Christina Gavino Anthony Cotter Daniel Lichtenstein Duncan Lejtenyi Claude Fortin Catherine Legault Najmeh Alirezaie Jacek Majewski Donald C Sheppard Marcel A Behr William D Foulkes Donald C Vinh

We demonstrate autosomal-recessive Caspase Recruitment Domain-containing protein 9 (CARD9) deficiency in a patient with relapsing C. albicans meningoencephalitis. We identified a novel, hypomorphic mutation with intact Th17 responses, but impaired GM-CSF responses. We report complete clinical remission with adjunctive GM-CSF therapy, suggesting that a CARD9/GM-CSF axis contributes to susceptibi...

Journal: :Blood 1994
P J Roberts A Khwaja A K Lie A Bybee K Yong N S Thomas D C Linch

The HL-60 model of myeloid maturation was used to test whether changes in signaling from the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor accompany maturation-related changes in cellular responses to GM-CSF. Receptor expression, tyrosine phosphorylation, functional activity, and c-fos gene expression were measured. Functional GM-CSF receptors were present throughout differ...

Journal: :The Journal of clinical investigation 1982
H E Broxmeyer

An association has been established between human Ia-like (Ia) antigenic determinants, expression during DNA synthesis on granulocyte-macrophage colony forming cells (CFU-GM) and the regulatory action of acidic isoferritins in vitro. Treatment of human bone marrow cells with monoclonal-anti-Ia-like (Ia) plus complement inhibited colony and cluster formation by approximately 50% but did not affe...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید