Contemporary systems of production, distribution, and retail provide many end-consumers, although certainly not all, with an unprecedentedly wide choice of cheap, high quality goods and services. Yet this bounty comes at ever higher, ultimately unsustainable environmental and social cost. Something must change but what and how? Simply how production, distribution and retail are organized? Simpl...

The function and normal regulation of calpain-3, a muscle-specific Ca(2+)-dependent protease, is uncertain, although its absence leads to limb-girdle muscular dystrophy type 2A. This study examined the effect of eccentric exercise on calpain-3 autolytic activation, because such exercise is known to damage sarcomeric structures and to trigger adaptive changes that help prevent such damage on sub...

A case is presented for the durability of anatomy including dissection of the cadaver and of morbid anatomy as elements in medical education and practice. It is these subjects, as consistently relevant over the centuries for medical practice as are communication skills, that are our hallmark as doctors. It is submitted that we should take stock very carefully of their relevance to us before it ...

BACKGROUND Specific immunological unresponsiveness to alloantigens can be induced in vivo by treating mice with a donor alloantigen in combination with a non-depleting anti-CD4 antibody. This tolerance induction protocol enriches for alloantigen reactive regulatory T cells (Treg). We previously demonstrated that alpha-1,2-mannosidase, an enzyme involved in the synthesis and processing of N-link...

Piezoelectric and Piezomagnetic materials like PbTio2, quartz, PbGaTio2 (Gallium Titanate) are quite susceptible to the implied stress respond proportionately in direction magnitude tn terms of electric voltage. The intensity, depends on configuration dimension material configurated, For desired voltage a demarcated coupling factor designed accordingly. Similar way piezomagnetic substances resp...