Background.  Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection has emerged as an important cause of morbidity and mortality. We determined the response to Truvada-based first-line combination antiretroviral therapy (cART) in HIV/HBV-coinfected verus HIV-monoinfected patients in Botswana. Methods.  Hepatitis B virus surface antigen (HBsAg), HBV e antigen (HBeAg), and HBV...

A 5 bp insertion was introduced into the BstEII site at nucleotide 2815 in DNA of hepatitis B virus (HBV) and a mutant HBV genome was produced, which coded for envelope and core proteins, but not for DNA polymerase, due to a frameshift. Cultured hepatoma cells (HepG2) were simultaneously transfected with a plasmid harbouring a tandem dimer of the mutant HBV DNA and another plasmid harbouring a ...

Background: We explored the effect of vitamin D receptor gene (VDR) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 μg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels a...

Chronic hepatitis B virus (HBV) infection has long been the most common cause of hepatocellular carcinoma (HCC). However, some aspects of the pathogenesis of HBV infection and genesis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) are still inconclusive. An increasing number of published studies indicate that hepatitis B virus mutations are associated with risk of HCC. These ...

background and aims: viral hepatitis is a global health problem with a high mortality rate. recently, a new flavi-like virus, provisionally named hepatitis g virus (hgv), has been described. hgv does not induce an immune response that is consistently detectable by using recombinant proteins from prokaryotic expression, therefore studies have been conducted by using polymerase chain reaction (pc...

Hepatitis B virus (HBV) and Hepatitis C virus (HCV) are the two most common blood borne, hepatotrophic viruses. HBV and HCV are important causes of liver related mortality and morbidity. Hepatitis B and hepatitis C are significant public health problems especially in developing countries like India. Hepatitis B was first reported in 1963 and hepatitis C in 1988 (Blumberg, 1997; Bonkovski et al....

background clinical observations have shown that patients infected with chronic hepatitis b virus (hbv) genotype c versus genotype b had a higher load of the virus, more serious illness, and poorer responses to antiviral therapy and prognosis. however, the disparity between the two has not been clarified. objectives to explore possible relationship between hbv genotypes b and c and peripheral b...

Fig. 1: Potential causes of liver enzyme elevations in HIV-infected patients. HBV, hepatitis B virus; HCV, hepatitis C virus; NASH, nonalcoholic steatohepatitis. Alcohol Drugs Medications HCV or HBV Chronic Hepatitis Drug-related Hepatotoxicity HIV HAART Other Liver Diseases: NASH*