abnormal function of the gastrointestinal tract, hepatobiliary system, and pancreas. It is published 12 times a year (monthly) by the publishes original articles pertaining to all aspects of research involving normal or AJP-Gastrointestinal and Liver Physiology

Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...

OBJECTIVES The aim of this study was to assess the diagnostic performance of a dynamic, multiphasic contrast-enhanced volume-interpolated sequence with advanced parallel imaging techniques, Dixon fat saturation, and view sharing with 5 hepatic arterial subphases for the detection of focal liver lesions. MATERIALS AND METHODS Twenty-four consecutive patients (13 females, 11 males; mean [SD] ag...

Twelve doctors with special training in hepatology independently reviewed two to five cases each from a group of seven cases of complicated hepatobiliary problems. A doctor's willingness to take risks to improve his patients' health was quantified by a wagering technique based on the probability of achieving a successful intervention. These probabilities were then used to calculate "utilities,"...

OBJECTIVE To extend the information base on the hepatobiliary manifestations of neonatal lupus erythematosus (NLE) with regard to frequency of occurrence, clinical characteristics, and outcome. METHODS Review of records from the Research Registry for Neonatal Lupus. RESULTS Nineteen (9%) of 219 patients who had NLE and were enrolled in a national registry had probable or possible NLE hepato...

AIMS AND BACKGROUND Hepatobiliary cystadenoma and cystadenocarcinoma are rare cystic lesions of the liver. The aim of the study was to discuss the clinical features, diagnostic methods and surgical treatment of hepatobiliary cystadenoma and cystadenocarcinoma in our hospital. METHODS Six patients with hepatobiliary cystadenomas and four with hepatobiliary cystadenocarcinomas were evaluated. W...

Cryptococcosis is a symptomatic fungal infection caused by Cryptococcus, which frequently occurs in patients who are immunologically compromised or chronically ill. Localized involvement of the hepatobiliary system in an immunocompetent adult is extremely rare. We report a unique case of isolated biliary cryptococcosis manifesting as obstructive jaundice and mimicking hilar cholangiocarcinoma i...

Primary sclerosing cholangitis (PSC) is a generally progressive, sometimes fatal chronic hepatobiliary disorder for which no effective medical therapy now exists. This article describes the epidemiology of this disease, along with diagnosis and treatment options. Future research directions concerning PSC also are discussed.

OBJECTIVE Since the approval of mercaptoacetyltriglycine (MAG3) for routine clinical use, reports have appeared about hepatobiliary excretion deleteriously affecting available diagnostic and quantitative information. The purpose of this study was to evaluate gallbladder (GB) uptake of MAG3 in the clinical setting and its effect on the evaluation of relative renal function and imaging. METHODS...