Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high prevalence and impact on society. ASDs are characterized by deficits in both social behavior and cognitive function. There is a strong genetic basis underlying ASDs that is highly heterogeneous; however, multiple studies have highlighted the involvement of key processes, including neurogenesis, neurite growth, s...

Autism spectrum disorders are a group of developmental disabilities characterized by atypical development in socialization, communication, and behavior. The term autism spectrum disorders describes three of the five pervasive developmental disorders, including autistic disorder, Asperger syndrome, and pervasive developmental disorder—not otherwise specified. Symptoms of autism spectrum disorder...

Chronic infectious diseases, including tick-borne infections such as Borrelia burgdorferi may have direct effects, promote other infections and create a weakened, sensitized and immunologically vulnerable state during fetal development and infancy leading to increased vulnerability for developing autism spectrum disorders. A dysfunctional synergism with other predisposing and contributing facto...

BACKGROUND Aberrant brain connectivity, especially with long-distance underconnectivity, has been recognized as a candidate pathophysiology of autism spectrum disorders. However, a number of diffusion tensor imaging studies investigating people with autism spectrum disorders have yielded inconsistent results. METHODS To test the long-distance underconnectivity hypothesis, we performed a syste...

This study examined the relations among loneliness, friendship, and emotional functioning in adults (N = 108) with autism spectrum disorders. Participants completed self-report measures of symptoms of autism spectrum disorders, loneliness, number and nature of friendships, depression, anxiety, life satisfaction, and self-esteem. The results indicated that loneliness was associated with increase...

Previous work leaves open the question of whether children with autism spectrum disorders aged 6-12 years have delay in producing gestures compared to their typically developing peers. This study examined gestural production among school-aged children in a naturalistic context and how their gestures are semantically related to the accompanying speech. Delay in gestural production was found in c...

Autism is a neurodevelopmental disorder with dimensional behavioral symptoms and various damages in the structural and functional brain. Previous neuroimaging studies focused on exploring the differences of brain development between individuals with and without autism spectrum disorders (ASD). However, few of them have attempted to investigate the individual differences of the brain features am...

Autism spectrum disorders (ASD) are highly heritable complex neurodevelopmental disorders with a 4:1 male: female ratio. Common genetic variation could explain 40-60% of the variance in liability to autism. Because of their small effect, genome-wide association studies (GWASs) have only identified a small number of individual single-nucleotide polymorphisms (SNPs). To increase the power of GWAS...

Background: Autism Spectrum Disorder (ASD) occurs based on the continuous deficit in a person’s verbal skills, visual, auditory, touch, and social behavior. Over the last two decades, one of the most important approaches in studying brain functions in autistic persons is using functional Magnetic Resonance Imaging (fMRI). Objectives: It is common to use all brain regions in functional extracti...