objective(s): genetic analysis of two consanguineous pakistani families with localized autosomal recessive hypotrichosis was performed with the goal to establish genotype-phenotype correlation. materials and methods: genomic dna extraction had been done from peripheral blood samples. extracted dna was then subjected to pcr (polymerase chain reaction) for amplification. linkage analysis was perf...

In order to assess the situation with air pollution by ozone in Colorado region during sunny part of the year (April to September), recently introduced photochemical pollution (PP) indicators have been applied on acquired ozone data, i.e. hourly ozone volume averages. PP indicators show very low values at the majority of stations except for the two located in Denver and Arvada which are located...

Intermediates play important roles in RNA folding but can be difficult to characterize when short-lived or not significantly populated. By combining (15)N relaxation dispersion NMR with chemical probing, we visualized a fast (kex=k1+k-1≈423 s(-1)) secondary structural switch directed towards a low-populated (∼3%) partially folded intermediate in tertiary folding of the P5abc subdomain of the 'T...