BACKGROUND AND PURPOSE Blood stasis is the fundamental mechanism leading to thrombus formation in the venous system. Homocysteine also poses a significant risk for venous thrombosis through its endothelial toxic and prothrombotic properties. In the present study, we hypothesized that high homocysteine might be associated with thrombus formation in another stasis-related condition, atrial fibril...

Chronic stress and anxiety in everyday life can lead to sympathetic hyperactivity. This be observed as behavioral, chemical, neurological changes, including increased rumination, anxiety, depression, chemical changes biological markers like homocysteine. In the EEG, beta (13–30 Hz) wave activity, especially high (> 20 has long been noted states. However, recent research indicates that low wa...

Elevated concentration of homocysteine (Hcy) in human tissues, definied as hyperhomocysteinemia has been correlated with some diseases, such as cardiovascular, neurodegenerative, and kidney disorders. Homocysteine occurs in human blood plasma in several forms, including the most reactive one, the homocysteine thiolactone (HTL) - a cyclic thioester, which represents up to 0.29% of total plasma H...

CONTEXT Although evidence suggests that homocysteine is a risk factor for cardiovascular disease in adults, little information exists on homocysteine levels in children. OBJECTIVES To describe the distribution of serum homocysteine concentrations among children and to examine the association between homocysteine levels and several characteristics, including serum levels of folic acid and vita...

Monshi Karimi AR1, Mohtadi-nia J2, Farhodi M3 1. M.Sc Student of nutritional sciences, Faculty of Health, Tabriz University of Medical Sciences 2. Associated professor, Department of Nutritional, Faculty of Health, Tabriz University of Medical Sciences 3. Assistant professor, Department of Internal, Faculty of medicine, Tabriz University of Medical Sciences Abstract Background: Isc...

Elevated blood levels of homocysteine are associated with atherosclerosis and thrombotic disease. We previously reported that treatment of cultured endothelial cells with homocysteine increased endogenous factor V activity by activation of the cofactor. Because endothelial cell-associated factor Va would be regulated by the protein C mechanism, the ability of homocysteine-treated arterial and v...

Homocystinuria is an autosomal recessive disorder usually caused by deficiency of cystathionine ␤-synthase, leading to grossly increased plasma and urine concentrations of homocysteine. There is considerable evidence that early detection and treatment can prevent the clinical consequences of the enzyme deficiency (1, 2); therefore, screening for the disorder has been advocated (1). Many cases o...

Background and Aim: Vitiligo is a hypopigmentation disorder of the skin that is associated with depression and an impaired quality of life. There has been conflicting reports on the association between the disease and the serum levels of homocysteine, vitamin B12, and folic acid.In this study,serum levels of homocysteine, vitamin B12, and folic acid were evaluated in patients with vitiligo.Meth...