introduction: [61cu]diacetyl-bis(n4-methylthiosemicarbazone) ([61cu]atsm) is a well-established hypoxia imaging tracer with simple production and significant specifity. in this work the accumulation of the tracer is studied in wild-type, necrotic and hypoxic fibrosarcoma tumors. methods: [61cu]atsm was prepared using atsm ligand and [61cu]cuoac followed by i.v. administration and imaging studi...

the purpose of this study was to investigate the potential responses of the cardiovascular system and regional blood flow to hypoxic hypoxia (bb) and to carbon monoxide (co)-induced hypoxia (coh). ten anesthetized cats were studied under two nonnoxic (control: cont) and two hypoxic conditions. four types of radioactive micro spheres were used to measure regional blood flow during cont and two h...

objective: transplantation of mesenchymal stem cells (mscs) can promote functional recovery of the brain after hypoxic-ischemic brain damage (hibd). however, the mechanism regulating msc migration to a hypoxic-ischemic lesion is poorly understood. interaction between stromal cell-derived factor-1α (sdf-1α) and its cognate receptor cxc chemokine receptor 4 (cxcr4) is crucial for homing and migra...

Hypoxia can induce cell damage, inflammation, carcinogenesis, and inhibit liver regeneration in non-adapted species. Because of their excellent hypoxia adaptation features, subterranean rodents have been widely studied to clarify the mechanism adaptation. Eospalax fontanierii , which is a rodent found China, survive for more than 10 h under 4% O 2 without observable injury, while Sprague-Dawley...

objective(s):pharmacological studies showed that the extracts of jin yin hua and its active constituents have lipid lowering, antipyretic, hepatoprotective, cytoprotective, antimicrobial, antibiotic, antioxidative, antiviral, and anti-inflammatory effects. the purpose of the present study was to investigate the protective effects of caffeoylquinic acids (cqas) from jin yin hua against hydrogen ...

Hypoxia exposure often cause the increases of pulmonary arterial pressure (PAP). Studies reported that mast cells (MCs) participate in vascular remodeling and promote formation chronic hypertension. Current studies mainly focus on change MCs under hypoxia, but few regulatory role mechanism acute hypoxia. T?herefore, present study investigated dynamic lung tissues hypoxia activation increasement...

Background. Training muscle capacities in hypoxic conditions increases some manifestations, such as hypertrophy and strength, due to a change the phenotype result of activation hypoxia-inducible factors (HIF). Despite proven benefits resistance training that allow conjecture regarding effectiveness facilitating muscular different populations, there is still controversy difference between hypoxi...