It has long been believed that nucleation of the a-helix is a very fast reaction, occurring in around 1027 s. We show here that helix nucleation, in fact, takes place on the millisecond time scale. The rate of a-helix nucleation in two polyalanine-based peptides and in lysine and glutamic acid homopolymers was measured directly by stopped-f low deep UV CD with synchrotron radiation as the light...

The emergence of new transport technologies coupled with deregulation and privatisation has contributed to thecontiguous growth of telecommunications networks particularly in terms of both the intricacy and size of the network.The rapid growth in network size, and intricacy, is of a concern to those who are involved in Network Management -particularly those involved with network...

There is much activity directed at quantifying the contribution of specific interactions to the stabilization of protein structure. The paper by Myers et al. (1) in this issue of the Proceedings addresses a central and much studied issue: The experimental measure of the intrinsic a-helix forming propensities of the amino acids. What is an intrinsic a-helix forming propensity? The idea that the ...

In this document we describe the scheme used for labelling the open-source Ukwabelana Zulu corpus as well as the rules employed for the Part-of-speech (POS) tagger used to assign POS to morphologically analysed words. A detailed description of the Zulu morphology, the corpus itself and its generation is given in [2]. All resources can be downloaded from http://www.cs.bris.ac.uk/Research/Machine...

Understanding mechanisms of reversibility in of hippocampal atrophy has taken on increased importance as the relationship between cortisol dysregulation and atrophy has become increasingly clear. Cushing’s disease provides a compelling model for understanding these mechanisms, particularly as atrophy is reversible following treatment to reduce the hypercortisolemia. The present study focused on...

Students’ acceptance and use of formative assessment feedback is expected to be impeded by negative attitudes towards their errors. Instruments to measure attitudes towards errors are currently lacking. The present study was designed to develop and begin to validate a self-report measure encompassing the affective, cognitive, and behavioral aspects of attitudes towards errors. Attitudes Towards...

21 The neuromodulator acetylcholine shapes neocortical function during sensory 22 perception, motor control, arousal, attention, learning and memory. Here we investigate 23 the mechanisms by which ACh affects neocortical pyramidal neurons in adult mice. 24 Stimulation of cholinergic axons activated muscarinic and nicotinic ACh receptors on 25 pyramidal neurons in all cortical layers and in mult...