LEPTIN (LEP) is a circulating hormone released primarily from white adipocytes and is crucial for regulating satiety and energy homeostasis in humans and animals. Using the CRISPR technology, we created a set of Lep mutant rats that carry either null mutations or a deletion of the 14(th) Ile (LEP(∆I14)) in the mature LEP protein. We examined the potential off-target sites (OTS) by whole-genome ...

The primary objective of this study was to determine the effectiveness of isometric exercise (IE) as a countermeasure to hindlimb unloading (HU)-induced atrophy of the slow (soleus) and fast (plantaris and gastrocnemius) muscles. Rats were assigned to either weight-bearing control, 7-day HU (H7), H7 plus IE (I7), 14-day HU (H14), or H14 plus IE (I14) groups. IE consisted of ten 5-s maximal isom...

this study was conducted to determine the possibility of a crop water stress index (cwsi) to schedule irrigation for pistachio tree under subsurface drip irrigation. the effects of two irrigation intervals consisting 3 (i3) and 14 (i14) days based on measuring soil water content were investigated on the cwsi. from 22 may (doy 143) to 22 september (doy 266), the evapotranspiration in i3 and i14 ...

This paper examines whether there is a causal relationship from job displacement to all–cause mortality. The hypothesis is tested for all employees who lost their job due to a plant closure in Sweden in 1987 and 1988. The control group is a random sample of all employees who did not experience a plant closure during the mid 1980s. Apart from variables commonly available in such studies (age, se...

To assess the importance of unequal access to medical expertise and services, we estimate causal effects having a child who is doctor on parents' mortality health care use. We use data from parents almost 22,000 participants in admission lotteries school Netherlands. Our findings indicate that informal services not an important cause differences mortality. (JEL H51, I11, I12, I14, I18)

This paper examines whether disease burdens, especially prevalent in the tropics, contribute significantly to widening gender gaps in educational attainments. We estimate the impact of sudden exposure to the 1986 meningitis epidemic in Niger on girls’ education relative to boys. Our results suggest that increases in meningitis cases during epidemic years significantly reduce years of education ...

Cost-sharing is regarded as an important tool to reduce moral hazard in health insurance. Contrary to standard prediction, however, such requirements are found to decrease utilization both of e cient and of ine cient care. I employ a simple model that incorporates two possible explanations consumer mistakes and limited access to assess the welfare implications of di erent insurance designs. I n...

TABLE O F CONTENTS INTRODUCTION ................................................................ I I I Material and methods ........................................................ 112 Variation of Jersey milk production with age at commencement of test.. ........ I14 Analytical constants describing the variation of milk production at different ages.. 119 The correlation of Jersey 8-months milk...