background : interleukin (il)-4 is a member of t helper 2 (th2) axis produced by t-lymphocyte and mast cell. it has been shown that il-4 expression changes in tumor tissues. the main objective of this study is to investigate the expression of il-4 mrna in patients with laryngeal squamous cell carcinoma (lscc) with or without lymph node involvement. materials and methods: mrna expression of il-4...

kawasaki disease (kd) is an acute vasculitis syndrome of unknown etiology. it occurs in infants and young children, affecting mainly small and medium-sized arteries, particularly the coronary arteries. generalized microvasculitis occurs in the first 10 days, and the inflammation persists in the walls of medium and small arteries, especially the coronary arteries, and changes to coronary artery ...

adenosquamous carcinomas of stomach are rare entities comprising 0.5% of stomach carcinomas. here, we report a case of a 50-year-old female, who presented with weakness, pallor, and symptoms of gastric outlet obstruction. a partial gastrectomy was done and histology showed evidence of adenosquamous carcinoma of the antrum with metastasis to the perigastric lymph nodes. the patient condition imp...

Sweat gland adenocarcinoma is a relatively uncommon malignancy. Clinical features are painless red or violet papules and nodules that can occasionally become ulcerated. The biological behavior is aggressive and metastatic sweat gland carcinoma spreads through the lymphatic. The treatment of choice is wide surgical excision with regional lymph node dissection. The portrayed ase was a 60-year-old...

background and objective: oral cancer accounts for less than 3% of all cancers. despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. several studies have been performed to assess factors influencing lymph node metastasis and prognosis. the aim of this study was to evaluate some clinical and pathological factors influencing lymph nod...

background: e-cadherin is a calcium-dependent molecule that contributes to intercellular adhesion. its proper functioning is important in the maintenance of epithelial structure and integrity. e-cadherin serves as a very important tumor suppressor. in this study, we aimâ to determineâ the frequencyâ of e-cadherin expression aberrancy and its relationship to theâ biologicalâ behavior of gastric ...

Lymph node involvement is a major prognostic variable in breast cancer. Whether the molecular mechanisms that drive breast cancer cells to colonize lymph nodes are shared with their capacity to form distant metastases is yet to be established. In a transcriptomic survey aimed at identifying molecular factors associated with lymph node involvement of ductal breast cancer, we found that luminal d...

BACKGROUND This study aimed to characterize the histopathological pattern of lymph node pathology among Saudi patients and to highlight the age and gender variations of these lesions as base line data. MATERIALS AND METHODS We retrospectively analyzed the data from lymph node biopsy specimens received at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia from January 2006...

Introduction: Medullary thyroid cancer (MTC) is an uncommon neoplasm originating from parafollicular C cells. Distant metastasis in MTC, such as axillary node involvement, is extremely rare.  Case Report: The present study describes a known case of MTC with axillary lymph node metastasis in a 31-year-old woman. In 2010, she underwent total thyroidectomy and right-sided modified radical neck dis...

  Introduction: Sentinel lymph node biopsy is the standard procedure for lymph node staging in intermediate thickness melanoma. In Iran, this procedure has not been addressed sufficiently. In this study, we report our experience in this area. Methods: Ten consecutive patients with intermediate thickness melanoma where included in our study. 1.5 mCi of Tc-99m antimony...