As encapsulation of hydrophilic drugs in the solid lipid nanoparticles (SLNs) is still a challenging issue, the aim of this study was to prepare SLNs containing tramadol hydrochloride as a hydrophilic compound.The SLNs were prepared using glycerol monostearate (GMS), soy lecithin and tween 80 by double emulsification-solvent evaporation technique. The nanoparticles were optimized through a cent...

abstract: background: a new type of drug delivery system known as mucoadhesive film has been developed for oral thrush treatment. due to comfortable use of this drug delivery system, this would be encouragingly utilized, especially in babies and patient under chemotherapy. nystatin mucoadhesive film (nmf) is a polymeric film which is adhered to front upper gum and back to the upper lip and rele...

the aim of the present study was to prepare and evaluate an osmotically controlled mucoadhesive cup-core (ocmc) containing aceclofenac. a special technique was used while preparing an ocmc. stability of ocmc was determined in natural human saliva, and it was found that both ph and device are stable in human saliva. ocmc was evaluated by weight uniformity, thickness, hardness, friability, swelli...

The current study aimed at in vitro investigating the kinetic study and thermodynamic analysis of mebendazole drug released from electrospun cellulose nanofiber in which guar gum is used as a release controller. The nanofibers were fabricated by electrospinning technique. The fibers were boosted by different controller guar gum 10 at 50, 250, and 500 ppm concentrations. The drug releas...

gel dosage forms are successfully used as drug delivery systems considering their ability to control drug release and to protect medicaments from a hostile environment. the aim of this work was to investigate the properties of carbopol 934p polymeric system in water-misible cosolvents such as glycerin and alcohol. benzocaine is a local anesthetic and the mucosal gel formulation is applied in th...

rivastigmine hydrogen tartrate (rht), one of the potential cholinesterase inhibitors, has received great attention as a new drug candidate for the treatment of alzheimer's disease. however, the bioavailability of rht from the conventional pharmaceutical forms is low because of the presence of the blood brain barrier. the main aim of the present study was to prepare positively charged eudragit r...

the present investigation deals with the development of controlled release tablets of salbutamol sulphate using graft copolymers (st-g-pmma and ast-g-pmma) of starch and acetylated starch. drug excipient compatibility was spectroscopically analyzed via ft-ir, which confirmed no interaction between drug and other excipients. formulations were evaluated for physical characteristics like hardness,...

        Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...

the aim of the present study was to develop and investigate the feasibility of delivering nebivolol as a transdermal patch by iontophoresis. the passive and electrically assisted transdermal delivery of nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. because of its extensive hepatic metabolism and low dos...