PURPOSE OF REVIEW Inclusion body myositis (IBM) is an enigmatic progressive disease of skeletal muscle. This review provides a summary of the clinical and pathophysiologic aspects of IBM. RECENT FINDINGS The development of diagnostic blood testing for IBM followed from the discovery of a B-cell pathway in IBM muscle and circulating autoantibodies against NT5C1A, further establishing IBM's sta...

the date of receipt and acceptance should be inserted later Abstract Inclusion systems have been introduced in algebraic specification theory as a categorical structure supporting the development of a general abstract logic-independent approach to the algebra of specification (or programming) modules. Here we extend the concept of indexed categories and their Grothendieck flattenings to inclusi...

682 Dn. SILVERMAN: I shall present the history of an infant who was admitted to our premature nursery on May 9, 1956. This Puerto Rican male infant was born during the thirtysixth week of an uneventful pregnancy. An antenatal serologic test for syphilis was negative. Delivery was spontaneous. Birth weight was 1070 gm. Physical examination on admission to the nursery revealed the liver to be 1 c...

We deene weak inclusion systems as a natural extension of inclusion systems. We prove that several properties of factorisation systems and inclusion systems remain valid under this extension and we obtain new properties as algebraic tools in abstract model theory.

Inclusion-body myositis is the most frequent and disabling myopathy seen in patients over 50 years of age. The distinct clinical features that lead to correct diagnosis and inclusion-body myositis mimics are highlighted. Inclusionbody myositis has a complex pathogenesis in which autoimmune and inflammatory features coexist with elements of degeneration and abundant accumulations of various stre...

Inclusion body myositis is an insidious, slowly progressive myopathy of middle-aged and older individuals. Because of these characteristics, diagnosis is often delayed. Affected muscle is marked by the presence of rimmed vacuoles, inclusions, and an inflammatory infiltrate largely made up of CD8 T lymphocytes and macrophages. The inclusions contain beta-amyloid and phosphorylated tau protein, a...

Liquid chromatography (LC) may be simply described as an analytical technique used to separate the individual components of a solution based on their relative afRnities for a liquid mobile phase and a stationary phase. There are numerous modes of LC (i.e. reversed-phase, normal-phase, ion exchange) that are commonly classiRed according to the mechanism by which separation occurs. One such mecha...

Differential inclusions represent an important generalization of differential equations. The solution to a DI is a reachable set, instead of a single trajectory. These concepts are well known in control theory, but not yet exploited in the field of modeling and simulation. The main applications may be related to the uncertainty in dynamic systems. The solving procedure for differential inclusio...