Conventional transdermal drug delivery systems (TDDS) have been designed for drug delivery through the skin. These systems use the permeability property of stratum corneum, the outermost surface layer of the skin. Applying polymeric micro and nanofibers in drug delivery has recently attracted great attention and the electrospinning technique is the preferred method for polymeric micro-nanofiber...

The article presents the results of a review publications devoted to study problems drug-induced liver damage in inflammatory bowel diseases (IBD). hepatotoxic effect thiopurines (azathioprine and 6-mercaptopurine) — hepatotoxicity from 0% 17%; sulfasalazine mesalamine (hepatotoxicity 4%); methotrexate 15% 50%); tumor necrosis factor inhibitors up 75% cases.), anti-integrins 2% 5%); an interleu...

Background: To explore the clinical efficacy, safety, and prevention of major adverse reactions non-steroidal anti-inflammatory drug celecoxib combined with OxyContin Pregabalin in treatment cancerous pudendal neuralgia.

Recent groundbreaking work in genetics has identified thousands of small-effect genetic variants throughout the genome that are associated with almost all major diseases. These genome-wide association studies (GWAS) are often proposed as a source of future medical breakthroughs. However, with several notable exceptions, the journey from a small-effect genetic variant to a functional drug has pr...