Abstract BACKGROUND Aberrant activity of the H3K27 modifiers EZH2 and BRD4 is an important oncogenic driver for atypical teratoid/rhabdoid tumor (AT/RT), each potentially a possible therapeutic target treating AT/RT. Thus, targeting distinct histone modifier activities would be effective approach METHODS The effects inhibition on modification, cell proliferation, invasion were analyzed by immun...

conclusions these results indicate that a. kellalensis extracts exert potent anti-rotaviral activity only after viral adsorption. the two extracts from a. kellalensis showed a good selectivity index. also these results suggest that extracts prepared from the flowers of a. kellalensis may be potential anti-rotaviral agents in vivo and be useful in veterinary medicine. background achillea kellale...

This paper aims to find out lactobacillu strains with cholesterol-reducing effect from crab paste. were isolated and purified the paste Ningbo, Zhejiang Province using MRS-CaCO3medium, probiotic properties of detected by gastric acid tolerance assay, bile salt determination bacterial inhibition ability, antioxidant activity assay. Following that, cholesterol-lowering screened o-phthalaldehyde m...

Ginseng extract (GE), ferulic acid (≥99%) (FA), and a fermented noni juice powder (FNJP) were analyzed for their antioxidant antimicrobial activities in vitro. Half inhibitory concentration (IC50) was 29.87, 0.45, 3.82 mg/mL, GE, FA, FNJP, respectively. The potential of the three extracts to inhibit polyphenol oxidase from vegetable matrices ranged between no inhibition 95.1% (depending on PPO ...

isolated five known iridoids glycosides (scrophuloside a, harpagoside b, 5-hydroxyloganin, 8-o-acetylharpagide and 6-o-methyl,1-glucopyranosyl catalpol ),one phenyl ethanoid glycoside (verbascoside) and a phenyl ethanol amine (2-(4-chlorobenzyl amino) ethanol ) compound from the methanolic extract of aerial parts of scrophularia oxysepala using by high performance liquid chromatography based on...

OBJECTIVE To evaluate changes of nuclear factor-kappa B (NF-κB) during radioiodine 131 ((131)I) therapy and whether NF-κB inhibition could enhance (131)I-induced apoptosis in differentiated thyroid cancer (DTC) cells in a synergistic manner. METHODS Three human DTC cell lines were used. NF-κB inhibition was achieved by using a NF-κB inhibitor (Bay 11-7082) or by p65 siRNA transfection. Methyl...

Phytochemical and antibacterial activity assay of methanol extract from Suji leaves (Pleomele angustifolia) were carried out. The aims this study are to determine secondary metabolites the against Streptococcus sobrinus KCCM 11898 mutans ATCC 25175 by using agar well diffusion. results showed that suji contain phenolic, triterpenoid steroid constituents. With 2%, displayed with diameter inhibit...

Artemisinin and its derivatives are very important new class of antimalarial drugs. One of the most important artemisinin derivatives is artemether. The antiparasitic activity of artemether as a derivative of artemisinin is related to endoperoxide bridge in its structure. The aim of this study was the evaluation of antileishmanial effect of artemether, with more focus on its apoptotic effect. I...

Artemisinin and its derivatives are very important new class of antimalarial drugs. One of the most important artemisinin derivatives is artemether. The antiparasitic activity of artemether as a derivative of artemisinin is related to endoperoxide bridge in its structure. The aim of this study was the evaluation of antileishmanial effect of artemether, with more focus on its apoptotic effect. I...