C YCLOSPORINE (CyA) and FK 506 are the effective immunosuppressive agents used in human organ transplantation and a variety of autoimmune diseases. 1-3 The nephrotoxicity of Cy A is well known. 4 • 5 Preliminary reports indicate the nephrotoxic nature of FK 506. though the clinical significance is yet to be established. especially in view of the favorable side effect profile that FK 506 possess...

introduction climate change is one of the most important challenges in sustainable development, which has a negative impact on aquatic and terrestrial ecosystems. this will change rainfall patterns the power to increase hurricane and the risk of drought, flood and will strengthen pressure on water resources. researchers generally agree that the main cause of the increase in global temperature i...

Bronchopulmonary sequestration is a rare congenital lung malformation characterized by an abnormal segment of bronchopulmonary tissue supplied by an anomalous systemic artery. The diagnosis may be easily missed in adults, as many of the symptoms overlap with other pulmonary processes. Surgical resection provides definitive management and is usually reserved for patients with symptoms. This arti...

Abstract Organic matter degradation and sequestration in marine sediments are important processes involved carbon cycling the ocean. Here, we present results of isotope ( 14 C 13 C) concentration measurements sedimentary organic (SOC), pore‐water dissolved (DOC), inorganic (DIC) collected from East China Sea, Yellow/Bohai South Sea. Our indicated that selective preservation occurred these sedim...

Autophagosome-lysosome fision measured by means o f electroinjected [ ‘“C] lactose While [‘“C] sucrose is an inert sequestration probe which eventually accumulates in lysosomes, [‘“c] lactose is hydrolysed immediately upon entry into the lysosome, by the lysosomal enzyme 0-galactosidase. Autophagically sequestered [“C] lactose therefore rapidly equilibrates at a low steady-state level, probably...

C-C chemokine receptor 5 (CCR5) is the primary coreceptor for human immunodeficiency virus type 1 (HIV-1) infection. Native chemokines that bind to CCR5 inhibit HIV-1 infection, albeit weakly, but chemically modified chemokines inhibit infection more efficiently. We have investigated the inhibitory mechanism of three N-terminally modified RANTES variants (AOP-, NNY-, and PSC-RANTES) with the MT...

Pulmonary sequestration has attracted considerable attention in recent years. Many papers reporting typical cases have appeared in the literature. Repetition of material already extensively reported will not be attempted (Bariety and Coury, 1947; Pryce, Sellors and Blair, 1947; Bruwer, Clagett and McDonald, 1950,1954; Kergin, 1952; Santy, Berard, Gaby and Huu (1952); Boyd, 1953; Hertzog, Toty, ...