A 35-year-old female had severe anaphylactoid reactions to pnlocaine and lignocaine on separate occasions Intradermal testing was positive to serial dilutions of both drugs and negative to bupivacaine, which was subsequently used uneventfully While intradermal testing for local anaesthetic allergy has limited application it would appear that when such te*ts are positive in high dilution they ma...

Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transderma...

Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transderma...

The ever-increasing interest in retaining a youthful physical appearance has facilitated the development of various minimally invasive dermatological techniques. The use of intradermal fillers can be incorporated into dermatological practices with minimal overhead costs. This strategy addresses facial volume loss and dynamic lines, which are the main features of facial aging. Moreover, intrader...

Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transderma...

UNLABELLED Allergen immunotherapy dates back to 1911 and has been used successfully to treat large numbers of patients throughout the last century. CASE REPORT a 66-year-old woman presented with symptoms of allergic rhinitis and asthma due to sensitization to Cupressus arizonica. Specific immunotherapy was prescribed as a continuous 2-year treatment with a depot preparation of standarized and...

Small doses of L2C leukemic cell suspensions inoculated intradermally into strain 2 and F1 hybrid guinea pigs induced leukemic tumors that regressed spontaneously in about 50% of animals, whereas s.c. inoculation induced uniformly generalized leukemia. Because of the behavioral differences between the s.c. and intradermal tumors, it appeared of interest to examine their comparative morphology b...

The second revived strain of culture vaccine virus has been propagated through 130 culture passages during a period of 3 years. It seems to be adapted to in vitro cultivation and still has an intradermal titer (rabbits) of 1 to 100,000 or 1 to 1,000,000. Intradermal inoculations in human beings of 0.1 cc. amounts of culture virus diluted from 2.5 to 10 times result in primary takes in unvaccina...

BACKGROUND This study compared the pharmacokinetics, postprandial glycemic response, and pain associated with intradermal lispro insulin delivery using a microneedle with that of a conventional catheter. SUBJECTS AND METHODS Five subjects with type 1 diabetes were administered a bolus infusion of lispro insulin using a 9-mm-long subcutaneous catheter (control treatment) and a 0.9-mm-long micr...

The effect of intradermal injection of leukotriene B4 alone and in combination with prostaglandin D2 and E2 and the effect of inhaled leukotriene B4 in combination with prostaglandin D2 were studied in six non-asthmatic men. The intradermal injection of leukotriene B4 (1 microgram) alone caused no immediate or late response in five of the six subjects but greatly potentiated the flare response ...