Human ether à-go-go 1 (Eag1) potassium channels are potential tumor markers and therapeutic targets for several types of malignancies, including cervical cancer. Estrogens and human papilloma virus oncogenes regulate Eag1 gene expression, suggesting that Eag1 may already be present in pre-malignant lesions. Therefore, Eag1 could be used as an earl...

This study aimed to screen for anal cancer and to determine its cytomorphology using liquid-based cytology (LBC) with specimens preserved in 95% ethyl alcohol. Anal swabs were collected for cytological examination from 177 adult, HIV-infected patients. After collection, sample slides were reviewed and classified according to their cytomorphology using the modified Bethesda 2001 system. An abnor...

OBJECTIVE To identify alterations in the cytokine profile and microbial ecosystem of the vagina in association with cervical dysplasia. METHODS Demographics, lifestyle variables and Papanicolau (Pap) smear results of subjects presenting to the same site for gynecologic complaints, obstetric visits or colposcopy were prospectively recorded. Vaginal smear for Gram stain, aerobic and anaerobic c...

BACKGROUND In Sweden approximately 40 000 women receive information annually that their Papanicolaou (Pap) smear test showed dysplasia and about 400 women are diagnosed with invasive cervical cancer. The aim of this study was to evaluate women 5 years after two consecutive Pap smears diagnosed with mild dysplasia (CIN 1), by describing their experience of receiving information about the results...

MATERIAL AND METHODS The current study analyzed the degree of agreement between HPV testing, Pap smear, and colposcopic directed cervical biopsies. The study was performed on a group of 332 patients diagnosed and treated for cervical dysplasia at Cuza-Vodă Obstetrics-Gynecology Clinic Hospital and Suceava County Hospital between 2006 and 2011. RESULTS 190 patients (57.23%) were positive for H...

attended our hospital for a surveillance colonoscopy. He had been diagnosed with left−sided ulcerative colitis, which had been well controlled by oral 5−ami− nosalicylic acid for 6 years. No active in− flammation was detected in the colon or rectum at colonoscopy, but a small whit− ish area with a clearly demarcated border, about 5 mm in size, was found in the low− er part of rectum (l" Fig. 1)...

Cytokines have an important role in the progression of cervical lesions and/or adenocarcinoma. We investigated whether polymorphisms at promoter regions IL-10 -1082 (A> G, rs1800896) and TNF-α -308 (G>A, rs1800629) genes were associated with susceptibility to dysplasia The study consisted 240 women infected HPV (72 adenocarcinoma 168 intraepithelial lesions), 169 healthy control women. Th...

BACKGROUND Cancer of the cervix is the commonest malignancy of the genital tract in Nigeria. In an atmosphere of opportunistic screening due to lack of a national screening programme, studies are needed to determine patients at risk of premalignant lesions of the cervix. GOAL To determine cervical smear pattern in patients with chronic pelvic inflammatory disease and investigate the potential...

OBJECTIVE To assess the prevalence of and factors associated with squamous intraepithelial lesions and condyloma [human papillomavirus (HPV)-related lesions) in HIV-infected patients. DESIGN A cross-sectional study in a tertiary-care university hospital conducted in 516 consecutive outpatients. INTERVENTION A systematic examination for macroscopic HPV-related lesions through anoscopy with h...