AIMS To determine how chronic hepatitis D virus (HDV) infection affects intrahepatic hepatitis B virus (HBV) antigen expression. METHODS Ninety eight liver biopsy specimens from 68 patients seropositive for total antibody to HDV were studied by immunohistochemistry, and the amount of HBV antigens was also quantified by radioimmunoassay in 12 patients and compared with 30 patients with chronic...

Biliary cast syndrome (BCS) is an unusual complication of orthotopic liver transplantation (OLT). BCS is characterized by multiple intrahepatic biliary strictures, ductal dilatation, intrahepatic abscesses, and biliary anastomotic leakage. The symptoms of BCS usually include high fever, jaundice and cholestatic liver enzyme elevation; similar to the symptoms observed in some patients with intra...

AIM To explore the effects of matrine (MT) on acute intrahepatic cholestasis induced by 17alpha-ethinyl estradiol (EE) in rats. METHODS Acute intrahepatic cholestasis in rats were induced by EE, and the effects of MT on acute intrahepatic cholestasis were explored and compared with ursodeoxycholic acid (UDCA) by serum biochemical determination and bile excretion experiments. RESULTS The ser...

A 65-year-old female presenting with hepatobiliary cystadenoma (HC) comprised of multiple cysts in the liver and a non-specific epigastric pain is reported herein.  Ultrasound study demonstrated dilated common bile duct (CBD) and intrahepatic bile ducts, plus two spherical stone-like bodies filling defects in the proximal CBD. Sphincterotomy and basket performed for the patient were not success...

Biliary infections and biliary cholangitis are common terms used to define infections of the biliary tree. Bacteria are the most common cause for these infections. Parasites can form an important group of biliary infections and act as causative agents or may predispose bacterial infections. Despite being an important cause, these infections are quite uncommon to find, especially in the intrahep...

CONTEXT Intrahepatic pancreatic pseudocyst extension is a rare but complex clinical entity requiring multimodality approach for management. There is no consensus regarding the optimal strategy for the treatment of intrahepatic pancreatic pseudocyst and the literature is limited to a few case reports. Most of the published cases were managed by surgical or percutaneous drainage. CASE REPORT We...

Congenital portosystemic shunts are present in one in 30,000 children. Among the associated risks of severe complications are neonatal cholestasis, benign and malignant liver tumors, hepatopulmonary syndrome, portopulmonary hypertension, and encephalopathy. They can be detected on prenatal ultrasonograms, during the investigation of a positive galactosemia screening test in neonates or of a com...

OBs-mucTivF jaundice is amenable to surgical treatment when the obstruction is extrahepatic. In recent years it has been recognised that the obstruction may be intrahepatic and the complete picture of obstructive jaundice may be seen without obstruction of the main bile ducts. It is important to differentiate between intrahepatic anid extrahepatic cholestasis in order to avoid unnecessary surgi...

The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded a general lack relevant disease controls. scarcity single-cell investigations in the broader population patients with CAP renders it difficult to distinguish immune features unique COVID-19 from common characteristics dysregulated host response pneumonia. We performed integrated...