نتایج جستجو برای: isis

تعداد نتایج: 2014  

Journal: :The Journal of pharmacology and experimental therapeutics 1997
S P Henry P C Giclas J Leeds M Pangburn C Auletta A A Levin D J Kornbrust

Intravenous infusion of high doses of phosphorothioate oligonucleotides in monkeys has been associated with transient alterations in hematologic and hemodynamic parameters, which appear to be secondary to complement activation. ISIS 2302, a phosphorothioate oligonucleotide specific for human intracellular adhesion molecule-1, was used to further characterize complement activation in monkeys. Co...

Journal: :Journal of neurophysiology 2008
P G Martin J E Butler S C Gandevia J L Taylor

These studies investigated whether a single electrical stimulus over the thoracic spine activates corticospinal axons projecting to human leg muscles. Transcranial magnetic stimulation of the motor cortex and electrical stimulation over the thoracic spine were paired at seven interstimulus intervals, and surface electromyographic responses were recorded from rectus femoris, tibialis anterior, a...

Journal: :Nucleic acids research 1998
L Benimetskaya G B Takle M Vilenchik I Lebedeva P Miller C A Stein

Cationic porphyrins form stable complexes with oligodeoxynucleotides. To evaluate delivery, we used a 20mer phosphorothioate oligomer (Isis 3521) targeted to the 3'-untranslated region of the PKC-alpha mRNA, and complexed it with porphyrin. The expression of PKC-alpha protein and mRNA in T24 bladder carcinoma cells was reduced by approximately 80 +/- 10% at a concentration of oligomer of 3 micr...

2015
Matteo Vergani Ana-Maria Bliuc MATTEO VERGANI ANA-MARIA BLIUC

In this article we investigate the evolution of ISIS by analysing the text contained in Dabiq, the official ISIS’ internet magazine in English. Specifically, we used a computerized text analysis pro-gram LIWC (Linguistic Inquiry and Word Count) to investigate the evolution of the language of the first 11 Issues of Dabiq. First, our analysis showed that affiliation seems to be an increasingly im...

2007
Doantam Phan J. Gerth M. Lee Andreas Paepcke Terry Winograd

This paper describes Isis, a system that uses progressive multiples of timelines and event plots to support the iterative investigation of intrusions by experienced analysts using network flow data. The visual representations have been designed to make temporal relationships apparent, allow visual classification of events with dynamic brushing, and enable users to organize their visualizations ...

Journal: :Neurocomputing 2003
Remus Osan Jonathan E. Rubin Rodica Curtu Bard Ermentrout

We study the existence of traveling waves in a one-dimensional network of integrateand-fire neurons with finite support coupling. We show that when the reset after spiking is sufficiently low, the interspike intervals (ISIs) for a traveling wave with an explicit first wave front can be computed. Further, we analytically derive a self-consistency equation that generates an explicit dispersion re...

2003
Remus Osan Jonathan Rubin Rodica Curtu Bard Ermentrout

We study the existence of traveling waves in a one-dimensional network of integrate-and-#re neurons with #nite support coupling. We show that when the reset after spiking is su2ciently low, the interspike intervals (ISIs) for a traveling wave with an explicit #rst wave front can be computed. Further, we analytically derive a self-consistency equation that generates an explicit dispersion relati...

Journal: :The Journal of pharmacology and experimental therapeutics 2002
Martin K Bijsterbosch Muthiah Manoharan Rick Dorland Richard Van Veghel Erik A L Biessen Theo J C Van Berkel

We previously modulated, by conjugating a single cholesterol, plasma protein binding and liver cell uptake of a phosphorothioate oligodeoxynucleotide (PS-ODN). In this study, we investigated the biological fate of a PS-ODN, denoted ISIS-9389 (3',5'-bis-cholesteryl-conjugated ISIS 3082), provided with two cholesteryl moieties. After intravenous injection of into rats, [(3)H]ISIS-9389 was cleared...

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