BACKGROUND AND OBJECTIVES A review of all the adjuncts for intravenous regional anaesthesia concluded that there is good evidence to recommend NonSteroidal Anti-Inflammatory agents and pethidine in the dose of 30mg dose as adjuncts to intravenous regional anaesthesia. But there are no studies to compare pethidine of 30mg dose to any of the NonSteroidal Anti-Inflammatory agents. METHODS In a p...

OBJECTIVE This study was conducted to determine the changes in blood pressure and the pulse rate of patients with controlled hypertension having dental extraction under local anaesthesia utilizing 2% lignocaine with adrenaline, and to evaluate whether these changes in blood pressure were are attributable to addition of adrenaline. METHODS This prospective study was carried out in 33 consecuti...

Topical anesthesia for flexible bronchoscopy can be achieved in several ways like administration of an anesthetic agents by injecting through cricothyroid membrane,by giving drug lignocaine through Nebulization, 3}administering the drug through oral spray. Nebulization of lidocaine can achieve very satisfying anesthesia comparable to oral spraying with significant low plasma levels of the drug....

Objective-To compare the anaesthetic properties of conventional intradermal 1% plain lignocaine with a topical gel preparation of adrenaline (1:2000) and cocaine (4-7%) for use in treatment of children's lacerations. Methods-Children aged 3-16 years with lacerations (not of the digits or mucous membranes) were consecutively assigned to receive either adrenaline and cocaine (AC) or lignocaine. P...

A recent review suggested using topical pharyngeal anaesthesia only in patients who prefer to be endoscoped without sedation. Topical anaesthesia was also found to be unnecessary in sedated patients in a subsequent study'. However the mean (range) dose of midazolam given to patients in this study was 8 mg (4-10). Using a lower dose of midazolam (mean dose = 5.2 mg ± 0.5 (2SEM) ), lignocaine spr...

OBJECTIVE Acute otitis media (AOM) is common in children, yet the optimal management of ear pain associated with AOM has not been well studied. We set out to determine the efficacy of topical aqueous 2% lignocaine eardrops compared with a placebo (saline) for pain relief of AOM in children. DESIGN Double-blind, randomised, placebo-controlled trial. SETTING Tertiary children's hospital emerg...

Propofol is frequently associated with pain on injection. We evaluated the effect of tramadol in a randomised, double-blind study using a tourniquet venous retention technique. Normal saline placebo was given intravenously to patients in Group 1 (n = 30),tramadol 50 mg to Group 2 (n = 30), and lignocaine 50 mg to Group 3 (n = 30). The venous retention of drugs was maintained for 1 minute, follo...

Intravenous lignocaine (1 mg./kg. body weight) was found to produce insignificant haemodynamic changes, and in particular no reduction in myocardial contractility. A rate of 2 mg./minute infused intravenously is suggested for therapeutic purposes.In anaesthetized dogs an infusion of 13.5 mg./minute caused moderate haemodynamic depression and a maximum plasma level of 7 mug./ml. Massive injectio...