For many years unfractionated heparin (UFH) was the only antithrombotic agent available in the United States. However, during the past decade new antithrombotic agents have become available. Th e fi rst of these agents were the low-molecular weight heparins (LMWHs) followed more recently by the direct anti-Xa inhibitors, of which only fondaparinux is available in the United States. Low-molecula...

Recent studies have indicated that certain low-molecular-weight heparins given subcutaneously may replace continuous intravenous unfractionated heparin for the treatment of venous thromboembolism. Low-molecular-weight heparins have a predictably high absorption rate when given subcutaneously and they do not require laboratory monitoring. These characteristics of low-molecular-weight heparin the...

The efficacy of low-molecular-weight heparin as a prophylactic agent was assessed in 150 consecutive patients over the age of 40 undergoing major abdominal surgery. Fifty of these patients received 1250 activated partial thromboplastin time (APTT) units of low-molecular-weight heparin every 12 hours: three developed isotopic deep vein thrombosis, which was confirmed by phlebography in two cases...

BACKGROUND AND PURPOSE There is no consensus whether to use unfractionated heparin or low-molecular weight heparin for the treatment of cerebral venous thrombosis. We examined the effect on clinical outcome of each type of heparin. METHODS A nonrandomized comparison of a prospective cohort study (the International Study on Cerebral Vein and Dural Sinus Thrombosis) of 624 patients with cerebra...

Heparin and the low molecular weight heparins are extensively used as medicinal products to prevent and treat the formation of venous and arterial thrombi. In early 2008, administration of some heparin lots was associated with the advent of severe adverse effects, indicative of an anaphylactoid-like response. Application of orthogonal analytical tools enabled detection and identification of the...

Variances and covariances were estimated for birth weight (BWT), weaning weight (WW), yearling gain (YG), yearling weight (YW), yearling height (YH), relative growth from birth to weaning (RGW) and weaning to yearling (RGY), and mature weight (MW). Field records on 572,446 Polled Hereford cattle were analyzed. Because multiple dam weights were collected on a cow the MW used in the analysis was ...

Heparin, a widely used anticoagulant, is being rapidly displaced by low-molecular-weight heparins. Recently, certain lots of heparin have been associated with anaphylactoid-type reactions resulting from contamination with oversulfated chondroitin sulfate. This impurity has also contaminated low-molecular-weight heparins obtained by chemical and enzymatic depolymerization of heparin. The sensiti...

OBJECTIVE To evaluate the efficacy and safety of two subcutaneous prophylactic regimens for postoperative deep vein thrombosis after total hip replacement. DESIGN Prospective open randomised multicentre trial. SETTING 28 European departments of orthopaedic surgery. INTERVENTION All patients had bilateral phlebography 10 days after surgery. 31 patients receiving low molecular weight hepari...