Protein-coated magnetic nanoparticles are promising candidates for various medical applications. Prior to their application into a biological system, one has to guarantee that the particle dispersions are free from pathogens or any other microbiologic contamination. Furthermore, to find entrance into clinical routine, the nanoparticle dispersions have to be storable for several months. In this ...

Viral safety is a prerequisite for manufacturing clinical antihemophilic factor VIII concentrates from human plasma. With particular regard to the hepatitis A virus (HAV), a terminal dry-heat treatment (100 degrees for 30 min) process, following lyophilization, was developed to improve the virus safety of a solvent/detergent-treated antihemophilic factor VIII concentrate. The loss of factor VII...

HYPOTHESIS Lyophilized plasma (LP) is as safe and effective as fresh frozen plasma (FFP) for resuscitation after severe trauma. DESIGN Multicenter animal study. SETTING Animal laboratories, 2 level I trauma centers. PARTICIPANTS Thirty-two Yorkshire crossbred swine. INTERVENTIONS Lyophilized plasma was analyzed for factor levels and clotting activity before lyophilization and after reco...

The necessity of measuring permeability is encountered in number applications and some them have adequate measurement techniques available. However, the fields freeze drying, composite scaffolds, 3D printed materials, etc., sample materials unique shapes sizes, which disables use standardized equipment. Hence, a novel method was developed to determine material by analyzing high frequency unstea...

Hampp (J. Am. Dental Assoc. 34:317, 1947) reported the successful recovery of six of seven spiral organisms from lyophilized material with the use of a complex medium unavailable through commercial sources. Annear (J. Bacteriol. 83:932, 1962; J. Gen. Microbiol. 27:341, 1962) recovered Reiter Treponeme and four strains of Leptospira from dried material by use of a prolonged and complex method. E...