OBJECTIVE To evaluate the association between time on mechanical ventilation and anthropometric, clinical and pulmonary function variables, measured early, in infants on invasive mechanical ventilation with acute respiratory failure due to viral bronchiolitis, and the temporal progression of variables with significant correlations. METHODS Twenty-nine infants admitted to the pediatric intensi...

Mechanical Ventilation provides a comprehensive theoretical background and practical approach to mechanical ventilation. It is written primarily for respiratory therapists, but critical care and respiratory physicians and nurses will find many aspects of the book invaluable, particularly the clear and concise descriptions of the different modes of mechanical ventilation, their advantages and di...

RATIONALE Nitric oxide (NO) produced in the lung is an important mediator of normal lung development, vascular smooth muscle relaxation, and ventilation perfusion matching. NO is synthesized from arginine by the action of NO-synthase (NOS). Asymmetric dimethylarginine (ADMA), an endogenous derivate of arginine, inhibits NOS and is thereby a determinant of NO synthesis. We compared ADMA and argi...

Respiratory syncytial virus (RSV) bronchiolitis causes severe respiratory tract infection in infants, frequently necessitating mechanical ventilatory support. However, life-saving, mechanical ventilation aggravates lung inflammation. We set up a model to dissect the host molecular response to mechanical ventilation in RSV infection. Furthermore, the response to induced hypercapnic acidosis, rep...

OBJECTIVE To analyze the characteristics of children with acute viral bronchiolitis subjected to mechanical ventilation for three consecutive years and to correlate their progression with mechanical ventilation parameters and fluid balance. METHODS Longitudinal study of a series of infants (< one year old) subjected to mechanical ventilation for acute viral bronchitis from January 2012 to Sep...

The relationship of vitamin D3 with the duration of mechanical ventilation and mortality is still unknown. Therefore, this study aimed to determine the effect of using high-dose vitamin D on the duration of mechanical ventilation among the patients admitted to the intensive care unit. The current double-blinded clinical trial was performed on 44 mechanically ventilated, adult patients. Us...

There is an increasing number of ventilated patients who require aerosol medications, for various indications. While there are many studies of aerosol delivery through tracheostomy and endotracheal tubes in patients on mechanical ventilation, and also in patients with noninvasive positive pressure ventilation,1 a relatively neglected area of aerosol therapy is in non-ventilated patients, and pa...

We are undertaking mechanical ventilation (MV) seriously since three years, begining with infants and children and then including neonates also. MV is provided to about 15 cases every month presently, 1 to 3 cases receiving it at a time. MV typically lasts for a few days, longest duration having been 37 days. Overall survival of 30% in 1992 is steadily improving. The following presentation of o...