One of the major problems in computational drug design is incorporation of the intrinsic flexibility of protein binding sites. This is particularly crucial in ligand binding events, when induced fit can lead to protein structure rearrangements. As a consequence of the huge conformational space available to protein structures, receptor flexibility is rarely considered in ligand design procedures...

The design of multiple degrees-of-freedom frames is critical in civil engineering, as these structures are commonly used various applications such buildings, bridges, and industrial structures. In this study, a six-degrees-of-freedom beam-column element stiffness matrix was formulated by superposition beam truss elements matrices adapted to statically analyze indeterminate frame development num...

By employing coarse-grained molecular dynamics simulation, we simulate the spatial organization of the polymer-grafted nanoparticles (NPs) in homopolymer matrix and the resulting mechanical performance, by particularly regulating the grafted chain length and flexibility. The morphologies ranging from the agglomerate, cylinder, sheet, and string to full dispersion are observed, by gradually incr...

With the development of the technology and increase of human dependency on structures, healthy structures play an important role in people lives and communications. Hence, structural health monitoring has been attracted strongly in recent decades. Improvement of measuring instruments made signal processing as a powerful tool in structural heath monitoring. Wavelet transform invention causes a g...

Mature market economies steadily raise full-benefit retirement ages and add flexible (or variable) age: early/late is punished/rewarded to neutralize the budgetary impact of free choice within wide age limits. New EU member states also ages, but typically restrict downward flexibility, conditioning it on long enough length contribution (e.g., Czechia) sometimes even forsake deduction (Females40...

A factor for estimating the flexibility of proteins is described that uses a cleavage method of "in-source decay (ISD)" coupled with matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). The MALDI-ISD spectra of bovine serum albumin (BSA), myoglobin and thioredoxin show discontinuous intense ion peaks originating from one-side preferential cleavage at the N-Cα bond of Xxx-As...