background: the presence of metastatic lymph nodes is the most important prognostic factor for gastric carcinoma; however, the optimal system for the accurate staging of lymph node metastasis for patients with gastric cancer remains controversial. this study was designed to compare five systems in relation to the n classification of gastric carcinoma. materials and methods: this multicentric hi...

Introduction: This study has investigated the correlation between IL-6 serum levels with distant metastatic breast cancer incidence. Methods: We recruited female patients at Dr. Soetomo General Hospital from March until May 2022. The sample was divided into 2 groups that consist Metastatic Breast Cancer (MBC) and non-MBC. After stage, were measured. design an observational analytic study, compa...

Breast cancer accounts for the majority of cancers in women worldwide, and most common overall UK. It is typically treated by a combination surgical medical therapies, which commonly include neoadjuvant and/or adjuvant chemotherapy. Neoadjuvant chemotherapy favour alongside surgery treatment breast confers no disease-free survival advantage. Nonetheless, favoured as first line therapy cancer. T...

Background: CD4+ and CD8+ T cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. The frequencies of T cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dLN) can be considered as useful markers for evaluation of the immune system in cancers. Methods: In this study,...

Background: Pericardial effusion (PE) due to secondary metastasis has rarely been reported in dogs. Case description: This case describes clinical signs and further diagnostics regarding metastatic carcinoma of unknown primary origin (CUP) in refractory PE of a dog. Findings/treatment and outcome: A nine-year-old, castrated mal...

Organotropism of cancer metastasis is driven by the ‘seed and soil’ theory where soil (metastatic microenvironment) provides signals to attract seeds (cancer cells) grow on a certain location. S100A8/A9 ‘soil sensing signal’ that binds receptors expressed many types. We aimed understand role in melanoma, breast lung cancer, develop neutralizing antibody, provide proof-of-concept for antibody in...

Mestastatic prostate cancer cells (MPCCs) frequently metastasize to bone, which is a “favorite soil” for colonization and proliferation of MPCCs. Prostate cancer bone mestastasis is tightly associated with tumor-induced bone lesions, most commonly caused from the etiological imbalance between osteoblastic bone formation and osteoclastic bone resorption, and from the anti-tumor immune response. ...

OBJECTIVES Population-based data on metastatic sites and survival in site-specific metastases are lacking for lung cancer and for any cancer because most cancer registries do not record metastases. This study uses a novel population-based approach to identify metastases from both death certificates and national inpatient data to describe metastatic pathways in lung cancer patients. MATERIALS ...

  A 57-year-old male with history of prostatectomy, cyctectomy, cecal urinary diversion for invasive prostate cancer and with a recent rise in PSA level, was referred for bone scintigraphy to rule out osseous metastatic disease. An interesting finding was abnormal tracer accumulation throughout the large bowel, which was proved to be due to urinary diversion.

objective: lactobacilli are a group of probiotics with beneficial effects on prevention of cancer. however, there is scant data in relation with the impacts of probiotics in late-stage cancer progration, especially metastasis. the present original work was aimed to evaluate the anti-metastatic and anti-proliferative activity of lactobacillus rhamnosus supernatant (lrs) and lactobacillus crispat...