Gene expression profiling of brain tissue samples applied to DNA microarrays promises to provide novel insights into the neurobiological bases of primate behavior. The strength of the microarray technology lies in the ability to simultaneously measure the expression levels of all genes in defined brain regions that are known to mediate behavior. The application of microarrays presents, however,...

BACKGROUND Most microarray data processing methods negate extreme expression values or alter them so that they do not lie outside the mean level of variation of the system. While microarrays generate a substantial amount of false positive and spurious results, some of the extreme expression values may be valid and could represent true biological findings. METHODS We propose a simple method to...

Microarray techniques have been widely used to monitor gene expression in many areas of biomedical research. They have been widely used for tumor diagnosis and classification, prediction of prognoses and treatment, and understanding of molecular mechanisms, biochemical pathways, and gene networks. Statistical methods are vital for these scientific endeavors. This article reviews recent developm...

Nowadays, in genomocentric era accelerated research of the human genome coupled with advances is enabling the comprehensive molecular profiling of human tissue. Particularly, DNA microarrays are powerful tools for obtaining global view of human non-Hodgkin lymphomas gene expression. Complex information from lymphomas “expression profiling” studies can, in turn, be used to create molecular marke...

Cancer, being one of the most taxing conditions requires functional studies to understand its complex and hetrogenous behavior. Microarray is powerful tool that allows the simultaneous analysis of the expression of thousands of genes or their RNA products on single platform. Proteome chip technology is a remarkable highthroughput method used to probe an entire collection of proteins and proved ...

Constructing an accurate predictive model for clinical decision-making on the basis of a relatively small number of tumor samples with high-dimensional microarray data remains a very challenging problem. The validity of such models has been seriously questioned due to their failure in clinical validation using independent samples. Besides the statistical issues such as selection bias, some stud...

UNLABELLED Nasal polyps, according to many authors, generate as a result of chronic inflammation process with activation of cytokines, immunological reaction mediators that regulate proliferation, differentiation and cell apoptosis. Clarifying molecular mechanisms present in those disturbances may have diagnostic and prognostic value in evaluation of recurrence, dynamics and differentiation of ...

Alexander Pope once wrote “Fools rush in where angels fear to tread.” In more recent times, Johnny Mercer wrote “fools rush in where wise men never go. But wise men never fall in love, so how are they to know.” Mercer’s words are perhaps indicative of where the field of microarray design and analysis is today. There is no question that fools (including the current author) have rushed into this ...

In recent decades, ongoing development of microarrays and microarray platforms has revolutionized biological research. Especially in cancer research, microarray technology has brought forth many new insights and has been widely applied for the elucidation of biological interrelations, effects, pathways and aetiology of cancers such as thyroid cancer (Kundel et al., 2010; Williams et al., 2011; ...