Introduction: Neuromyelitis Optica (NMO) is a rare inflammatory disease of the central nervous system which generally affecting the spinal cord and optic nerve. Damage to the optic nerve can result in the patient's dim vision or even blindness, while the spinal cord damage may lead to sensory and motor paralysis and the weakness of the lower limbs in the patient. Magnetic Reson...

Functional MRI (fMRI) of cognitive tasks depends on technology widely available in the clinical sphere, but has yet to show a role in the investigation of patients. We report here the first demonstration of a clinically valuable role for cognitive fMRI. Temporal lobe epilepsy (TLE) is commonly caused by hippocampal sclerosis and is frequently resistant to drug treatment. Surgical resection of t...

Cognitive dysfunction often accompanies diabetes. Both hypoglycemia and hyperglycemia cause cognitive dysfunctions. However, the underlying pathophysiology remains unclear. Recent evidence show that ferroptosis primarily triggers nerve cell death, Alzheimer’s disease (AD), Huntington’s (HD), Parkinson’s (PD). The present study aimed to investigate whether is a vital pathogenic pathway in diabet...

The mechanisms underlying the effects of electroconvulsive therapy (ECT) in major depressive disorder (MDD) are not fully understood. Resting-state functional magnetic resonance imaging (rs-fMRI) is a new tool to study the effects of brain stimulation interventions, particularly ECT. The authors aim to investigate the mechanisms of ECT in MDD by rs-fMRI.They used rs-fMRI to measure functional c...

Functional magnetic resonance imaging (fMRI) has been shown to detect the specificity of acupuncture points, as proved by numerous studies. In this study, resting-state fMRI was used to observe brain areas activated by acupuncture at the Taichong (LR3) acupoint. A total of 15 healthy subjects received brain resting-state fMRI before acupuncture and after sham and true acupuncture, respectively,...

BACKGROUND Recent functional MRI (fMRI) studies have demonstrated that there is an intrinsically organized default mode network (DMN) in the resting brain, primarily made up of the posterior cingulate cortex (PCC) and the medial prefrontal cortex (MPFC). Several previous studies have found that the DMN is minimally disturbed during different resting-state conditions with limited cognitive deman...

conclusions the current study adds evidence to the association of tnf-α gene polymorphism and ms in this southern south iranian population which is consistent with the genetic analysis of ms in europeans (games) project reports and these two alleles reported in this study may be one of the genetic risk factor for ms. furthermore, this data can be used to build the iranian gene bank for future s...

background: the clinical course of multiple sclerosis (ms) evolves over many years. its prognosis is highly variable among affected individuals, i.e. while some suffer from early severe disabilities, others remain ambulatory and functional for many years. we used multiple sclerosis severity score (msss) and the new classification for ms severity herbert et al. introduced in 2006 according to ms...

The present study explored the relationship between visual dorsal stream and Chinese reading by resting-state fMRI technique. We collected the resting-state brain activities and reading skills of Chinese-speaking adult readers. The results showed that the values of amplitude of low frequency fluctuation (ALFF) in right posterior parietal cortex (PPC) and left visual middle temporal area (MT) (t...