Duchenne muscular dystrophy is a lethal muscle wasting disorder, resulting from mutations in the gene encoding for the skeletal muscle protein dystrophin. The absence of functional dystrophin leaves the muscle membrane vulnerable to damage during contraction. Damage initially occurs as 'tears' in the membrane, this damage can be exacerbated by the inflammatory response leading to myofibre necro...

Limb lengthening by Ilizarov lengthens not just the long bone, but also the soft tissues too. Damage of the musclesduring corticotomy and their stretching during distraction play a crucial role in occurrence of complications and finallimb function. We present here a systematic codified nomenclature system of each muscle summarising all theinfluence that corticotomy and distraction have the part...

Exercise-induced muscle injury in humans frequently occurs after unaccustomed exercise, particularly if the exercise involves a large amount of eccentric (muscle lengthening) contractions. Direct measures of exercise-induced muscle damage include cellular and subcellular disturbances, particularly Z-line streaming. Several indirectly assessed markers of muscle damage after exercise include incr...

BACKGROUND High-intensity of exercise or unaccustomed eccentric exercise can cause the phenomenon of Exercise-Induced Muscle Damage (EIMD) which usually results in cramps, muscle strain, impaired muscle function and delayed-onset muscle soreness. OBJECTIVES This study investigated the prophylactic effects of sauna towards the symptoms associated with muscle damage from eccentric exercises of ...

The sarcopenia, charaterised by a decrease in muscle mass associated with reduced physical activity, is a direct cause of the age-related loss of muscle strength. Studies previously performed in our laboratory show, in human vastus lateralis muscle, a direct correlation between age and oxidative damage to biological molecules. The reactive oxygen species are involved not only in muscle damage b...

Muscular adaptation which occurs following eccentric exercise-induced muscle damage has been associated with changes in the mechanical properties of muscle manifested as a shift in the length-tension relationship towards longer muscle lengths. However, it is not clear whether this shift is a long term adaptation to eccentric exercise. The purpose of this study was to investigate functional adap...