INTRODUCTION Phosphatidylethanolamine (PE)-conjugated nanoliposomes were developed, characterized, and investigated for their accumulation in liver, kidneys, and lungs in rats. METHODS Drug-excipient interaction was studied using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), surface morphology by field emission scanning electron microscopy, elemental...


 Purpose: To prepare, characterize and investigate the stability drug release profile of silver sulfadiazine (AgSD) nanoliposomes as functions pH, UV exposure, and/or heat.
 Methods: Silver were prepared. The properties free nanoliposomal formulations AgSD heat analyzed. analyses performed at different time points.
 Results: results characterization showed that acidic, basic neu...

Omega-3 fatty acids (FAs) have been shown to prevent cardiovascular disease. The most commonly used omega-3 fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are highly vulnerable to oxidation and therefore, have short shelf life. Recent advances in nanoliposomes provided a biocompatible system for stabilizing omega-3 FAs. Several methods could be implemented to prepar...

Intestinal inflammation, especially chronic (such as inflammatory bowel disease [IBD]), is an indispensable participant in the colonic neoplastic process, fostering proliferation, survival, and migration of tumor cells. Molecularly targeted therapeutics (e.g. anti-TNF-α agents) that exploit targets involved pathophysiology responses IBD are most potent drugs currently available to treat IBD, wh...

Oral aphthous stomatitis is a common disorder treated with the immunomodulatory drug Amlexanox (AMX), that was administered as mucoadhesive paste (Aphthasol®). This product discontinued by FDA in 2014 due to associated undesired adverse reactions of formulation. Here, we have developed AMX-loaded nanoliposome formulation potential alternative for localised oromucosal delivery AMX. Nanoliposomes...

Objective (s): This study aimed at investigation of preparation and stability study of Mitomycin and Mitomycin loaded nanoliposems and efficacy of the combination of Mitomycin -loaded nanoliposomes and Curcumin versus Mitomycin in suppressing HTB-9 and L929 cell lines, in vitro.Materials and Methods: An HPLC method was validated based on Q2 (R1) International Conference on Harmonization (ICH) g...

Natural food antimicrobials are bioactive compounds that inhibit the growth of microorganisms involved in food spoilage or food-borne illness. However, stability issues result in degradation and loss of antimicrobial activity. Nanoencapsulation allows protection of antimicrobial food agents from unfavorable environmental conditions and incompatibilities. Encapsulation of food antimicrobials con...

The purpose of this study was to investigate flexible nanoliposomes for mediating topical delivery of daptomycin, and to document permeation rates and bacteriostatic activity towards skin infections. Response surface methodology was used to optimize the daptomycin-loaded flexible nanoliposomes (DAP-FL), and the amount of drug loaded into the particles was evaluated as the investigation index. T...