The effect of thyroxine on membrane bound (Na+, K+)-ATPase isolated as a microsomal fraction from rabbit heart and kidney was investigated. In the heart, thyroxine administration produced an increased Ki value (a concentration of ouabain required for half maximal inhibition of (Na+, K+)-ATPase activity) without alteration of the specific activity of cardiac (Na+, K+)-ATPase, indicating that the...

The susceptibility to the toxic arrhythmogenic effects of digitalis was studied in to normal dogs (group 1) and in 15 dogs with healed myocardial infarction (group 2) 26 ± 5 days after coronary artery ligation. The dose of ouabain required to cause stable digitalis-toxic ventricular tachycardia was 25% less in the group 2 dogs than in the group 1 control dogs (70 ± 21 versus 93 ± 16 J.tg/kg, pr...

introduction: anorexia nervosa is an eating disorder in which a person refuses to stay at even the minimum body weight considered normal for their age and height. persons with this disorder may have an intense fear of weight gain and a distorted body image. inadequate eating or excessive exercising results in severe weight loss. the exact cause of anorexia nervosa is not known, but social attit...

The interrelated effects of digitalis and various cations on cardiac rhythmicity are the subject of much recent interest. This paper presents additional data on this subject that carry important therapeutic implications. The chelating agent, disodium ethylene diamine tetra acetate (NaEDTA), has been used intravenously in 14 instances of supraventricular and ventricular arrhythmia. Digitalis had...

This paper discusses the irruption of digital faithful generation Z in Indonesian Catholic church and its disruption to citizenship catechesis. The discussion catechesis will fall short if we still fixate on classic definitions catechesis, method profile catechists apostolic exhortation Cateceshi Tradendae (1979). predigital world conditions ideas about them. An in-depth discourse needs depart ...

The determination of the state of digitalization in a given patient is often difficult and at times impossible. Although Eggleston1 indicated that the required quantity of digitalis is a function of body weight, the digitalizing dose is an empiric and occasionally a dangerous assumption. Clinically, the classical symptoms of digitalis intoxication may mimic those of circulatory failure. Nausea,...

Diphenylhydantoin sodium (Dilantin) given prophylactically increased the dose of digitalis necessary to produce toxicity by 72 to 224%. At constant heart rates, pretreatment with diphenylhydantoin sodium did not alter the elevation of rate of rise of left ventricular pressure produced by the glycoside. Two implications have been drawn from these findings. First, the inotropic and arrhythmic act...

OBJECTIVE Although anorexia nervosa has a high mortality rate, our understanding of the timing and predictors of mortality in eating disorders is limited. The authors investigated mortality in a long-term study of patients with eating disorders. METHOD Beginning in 1987, 246 treatment-seeking female patients with anorexia nervosa or bulimia nervosa were interviewed every 6 months for a median o...

The use of digitalis has been plagued by controversy since its initial use by Withering in 1775. We now have much more data,1 but it should be remembered that the Digitalis Investigator Group trial was executed when -blockers were not widely used to treat heart failure. There are still many questions about where we currently stand with the use of digitalis. Specifically, when should one add dig...