The primary toxicity of oxaliplatin is neurotoxicity. Calcium and magnesium (Ca/Mg) are reported to be beneficial in protecting against this adverse effect. However, the results obtained from clinical trials are not definitive. The aim of this study was to evaluate whether Ca/Mg alleviates the neurotoxicity of oxaliplatin by performing a meta-analysis of the literature involving available rando...

Pyrethroid insecticides have been used for more than 40 years and account for 25% of the worldwide insecticide market. Although their acute neurotoxicity to adults has been well characterized, information regarding the potential developmental neurotoxicity of this class of compounds is limited. There is a large age dependence to the acute toxicity of pyrethroids in which neonatal rats are at le...

Objective(s):Acrylamide (ACR) has many applications in different industries. ACR damages the central and the peripheral nervous system in human and animals. Importance of ACR-induced neurotoxicity encouraged researchers to find both different mechanisms involved in ACR neurotoxicity and potent neuroprotective agents. Therefore, this study was designed to investigate the protective effect of cro...

conclusions with regard to the potent antioxidant properties of silymarin, the neuroprotective effects of this natural compound suggested in the current study may in part be mediated through inhibition of oxidative stress. results exposure to acr reduced cell viability in pc12 cells. pre-treatment of cells with silymarin (100 µm) significantly reduced acr-induced toxicity. in addition, administ...

BACKGROUND AND PURPOSE Transplantation conditioning regimens have been shown to affect the brain imaging appearance in patients with cyclosporine or FK-506 neurotoxicity. We assessed whether the occurrence of neurotoxicity was affected by the choice of conditioning regimen used before allogeneic bone marrow transplantation (allo-BMT). METHODS An allo-BMT was performed in 290 patients conditio...

This review, covering a timespan of almost a century, attempts to answer five pressing questions: (1) Are intraspinal steroid therapies eVective for back pain or radicular syndromes? (2) Do epidural injections remain confined to the epidural space? (3) Are presently prescribed steroid formulations neurotoxic? (4) What are the risks of epidural steroid injection? (5) What information should be g...