The mechanisms by which endotoxins mediate neutrophil transepithelial migration and lung inflammation are unclear. It was hypothesized that both the presence and orientation of epithelial cells are critical to endotoxin-induced neutrophil migration. Neutrophil migration was compared through naked filters and filters with A549 lung epithelial monolayers grown on the upper and lower surface of pe...

INTRODUCTION Neutrophil CD64 has been proposed as an early marker of sepsis. This study aims to evaluate the diagnostic utility of neutrophil CD64 for identification of early-onset sepsis in preterm neonates. METHODS The prospective study was conducted in a neonatal intensive care unit between November 2010 and June 2011. Preterm neonates in whom infection was suspected when they were <12 hou...

objective(s) lipocalin 2 (lcn2) is a 25-kda glycoprotein that has initially been extracted from neutrophil granules. expression of lcn2 is induced under various pathophysiological conditions. it is also known as an early marker of kidney and heart injury. high-level expression of recombinant lcn2 neutrophil gelatinase-associated(ngal) in insect cells was the aim of this study. materials and met...

background: the study was designed to assess the role of preoperative neutrophil, lymphocyte, and neutrophil?lymphocyte ratio (nlr) in predicting survival outcomes of abo?incompatible liver transplantation (lt). materials and methods: we retrospectively collected the demographic and clinical  characteristics of 71 patients with end?stage liver cirrhosis following abo?incompatible lt in this stu...

Background and objectives: In patients with coronavirus disease 2019 (COVID-19), white blood cell (WBC) abnormalities have been found worldwide with significant inter-regional differences. In the present study, we evaluated WBC parameters concerning COVID-19 positivity and severity. Methods: In this cross-sectional study, total WBC count, absolute count of each type of WBC, neutrophil to lymph...

1. Close contact between platelets and neutrophils modulates their cellular interactions in thrombotic and inflammatory states, with stimulation of P-selectin expression on platelets by agonists such as thrombin and neutrophil-derived cathepsin G being critical in mediating platelet-neutrophil adhesion. This study compared the effects of thrombin and cathepsin G on platelet P-selectin expressio...

The goal of this study was to evaluate annexin V-positive microparticles (MPs) and neutrophil activation in humans following decompression from open-water SCUBA diving with the hypothesis that changes are related to intravascular bubble formation. Sixteen male volunteer divers followed a uniform profile of four daily SCUBA dives to 18 m of sea water for 47 min. Blood was obtained prior to and a...

Neutrophils are essential for maintaining innate immune surveillance under normal conditions, but also represent a major contributor to tissue damage during inflammation. Neutrophil homeostasis is therefore tightly regulated. Cxcr2 plays a critical role in neutrophil homeostasis, as Cxcr2(-/-) mice demonstrate mild neutrophilia and severe neutrophil hyperplasia in the bone marrow. The mechanism...

A mathematical model of neutrophil and granulocyte colony stimulating factor (G-CSF) dynamics is developed to capture the response of circulating neutrophil levels to inflammatory and anticancer drug challenges. Severe infection or trauma induces inflammation, leading to: (i) the recruitment of neutrophils to the site of infection; (ii) misdirected neutrophil recruitment to healthy tissue, whic...