Loratadine is an efficacious, non-drowsy antihistaminic molecule prescribed for allergic skin. The conventional oral dosage form associated with various side effects, limited and variable absorption. present study attempts to improve the effectiveness of drug by formulating a niosome loaded hydrogel loratadine treating Ether injection method was used prepare niosomes using Box Behnken design. P...

Skin is an important organ of the body due to offering an accessible and convenient site for drug administration. One of the disadvantages of transdermal drug delivery is the low penetration rate of drugs through the skin. Over the past decades, nanoparticles have been used as drug delivery systems to increase therapeutic effects or reduce toxicity. Encapsulation of drugs in nanoparticulate ves...

Multilamellar vesicles (noisome) of polyoxyethylene alkyl ether surfactants (Brij 52, 72, 76 and 92) were prepared using classic film hydration method. Vesicle formation ability of the surfactants was assessed in presence or absence of cholesterol. All used surfactants formed vesicles in the absence of cholesterol. Recombinant human insulin was used as a model protein drug to investigate encaps...

The emerging technology of drug-encapsulated nanoparticles plays a critical role in the development of treatment for various life-threatening diseases due to the versatility, control, and future potential of the design of these systems. A current treatment technique for the treatment of brain tumor cells, after major surgery, utilizes a drug adhered to a biodegradable polymer wafer that provide...

Abstract: Introduction: Formulation of a nano lipid carrier loaded hydrophilic gel corticosteroid, fluticasone propionate (FP) was investigated systemically with response surface model (RSM) for promising dermal delivery the drug. Objectives: To achieve better penetration drug and to overcome generally associated adverse reactions corticosteroids, present study, explored formulation evaluation ...

      In this work we sought to determine whether vesicles (liposomes/niosomes) were able to enhance finasteride concentration in the dermis layer, including the pilosebaceous units (PSU). Such enhancement could be beneficial in the treatment of some androgen-related skin disorders. Hamster flank skin was used to study  <span styl...

Introduction: Etodolac is used in the treatment of acute pain and inflammation. It has low solubility because high hydrophobicity it reported that upon oral administration shows gastric disturbances. This encourages development topical vesicular formulation.&#x0D; Method: In this work we coacervation-phase separation method for etodolac loaded system by using non-ionic surfactants, cholesterol ...