background: the present study was conducted to investigate the optimized timing for macrophages induction and nitric oxide (no) production against invading leishmania parasite. methods: the present study examined the murine macrophage cell line, b10r, in three different states. in the first state, the cells were first infected with l. major and then treated with ifn-g and lps as stimulants. in ...

introduction: nitric oxide (no), as a free radical, involves in several physiologic functions in gi tract such as nerve impulse transmission and vascular tonicity regulation. nitric oxide synthase (nos) is the enzyme for the production of no from l-arginine which in turn inhibits by l-ngnitroarginine methyl ester (l-name). in the current work, we aimed to evaluate morphometric analysis of duode...

Transcription of ResDE-controlled genes in Bacillus subtilis was induced by sodium nitroprusside and nitric oxide. This induction requires the sensor kinase ResE and the response regulator ResD. Among members of the ResDE regulon, only the flavohemoglobin gene was induced by nitrosative stress via both a ResDE-dependent mechanism and an unidentified ResDE-independent mechanism.

BACKGROUND Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood. METHODS The authors investigated the fate of inhaled nitric oxide (80 parts per million) in mice and quantified the formation of nitric oxide metabolites in blood and tissues....

Tungsten trioxide is the second most commonly used semiconducting metal oxide in gas sensors. Semiconducting metal oxide (SMOX)-based sensors are small, robust, inexpensive and sensitive, making them highly attractive for handheld portable medical diagnostic detectors. WO₃ is reported to show high sensor responses to several biomarkers found in breath, e.g., acetone, ammonia, carbon monoxide, h...

A sensitive electrochemical sensor was fabricated for selective detection of nitric oxide (NO) based on electrochemically reduced graphene (ErGO)-polyaniline (PANI)-gold nanoparticles (AuNPs) nanocomposite. It was coated on a gold (Au) electrode through stepwise electrodeposition to form AuNPs-PANI-ErGO/Au electrode. The AuNPs-PANI-rGO nanocomposite was characterized by Field Emission Scanning ...

increased nitric oxide (no) formation is mechanistically linked to pathophysiology of the extrahepatic complications of cirrhosis. no is formed by either enzymatic or non-enzymatic pathways. enzymatic production is catalyzed by no synthase (nos) while entero-salivary circulation of nitrate and nitrite is linked to non-enzymatic formation of no under acidic ph in the stomach. there is no data on...

abstract introduction: matrix metalloproteinase 2 is one of the inflammatory mediators that is involved in nociceptive processing and its production is regulated by many inflammatory factors such as nitric oxide. we studied the role of mmp-2 on the analgesic effects of nnos inhibitor. methods: considering that nitric oxide has many roles in pain processing, we studied the csf levels of mmp-2 af...

introduction: cigarette smoking affects nitric oxide production. the aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (nox) concentration. methods: serum nox concentration was measured by the griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. subjects were selected from participants of tehran lipid and gluco...