The main features of Christmas disease, a hereditary disorder of blood coagulation, are outlined, and a family of coal-miners who suffer from this disorder is described. The affected male members of two generations have spent their working lives underground. Three of the eight affected miners were temporarily severely disabled by episodes associated with their bleeding diathesis, and one died i...

OBJECTIVE MQX-503 is a novel nitroglycerine preparation designed to absorb quickly and allow local vasodilatation in the skin. We examined the efficacy and tolerability of this medication in Raynaud phenomenon (RP) in a laboratory-based study. METHODS In this multi-centre, double-blind, randomised, placebo-controlled, cross-over study, subjects were treated with 0.5% or 1.25% nitroglycerine o...

This of pape Add Chicag 1 Pre Abstract—Nitroglycerine has been used clinically in the treatment of angina for 130 years, yet important details on the mechanism of action, biotransformation, and the associated phenomenon of nitrate tolerance remain unanswered. The biological activity of organic nitrates can be said to be nitric oxide mimetic, leading to recent, exciting progress in realizing the...

Background: Preterm birth continues to be a problem for obstetricians. complicates 8-10% of birth. Although the causes preterm labor are not well understood, burden is clear. Aim and objectives: The aim was study evaluate efficacy safety transdermal nitroglycerin as tocolytic agent in women with labor. Subjects methods: This prospective randomized controlled trial conducted obstetrics Gynecolog...

The haemodynamic effects of infusing sodium nitroprusside or trinitroglycerine to control hypertension during operation were compared in 22 patients undergoing coronary artery surgery. Measurements were taken before induction of anaesthesia, during median sternotomy, and upon attainment of a stable decrease in arterial pressure. Both drugs significantly decreased arterial pressure without affec...