cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. cancer vaccines induce pe...

The aim of this study was to investigate the effect of red pepper (Capsicum annuum) extract on growth, blood, biochemical and non-specific immune parameters of 360 rainbow trout (Oncorhynchus mykiss) juveniles with average weight of 9.38±0.01 g. The fish were fed with a commercial diet containing 0, 0.25, 0.5 and 1% of C. annuum extract in 12 tanks (300L) with three replicates (30 fish per tank...

Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Meth...

Background & Objective: DNA vaccines as a new generation of vaccines require adjuvant to improve vaccine immunogenicity; adjuvants can also increase the DNA vaccine efficacy. In this study, the effects of the host’s interferon-inducible Mx protein as bio adjuvant and conventional alum adjuvant were evaluated.   Materials & Methods: The BALB/c mice were immunized by different prime-boost strate...

BACKGROUND: The immunostimulating effect of Aloe vera in mammals has been documented, but few works were done on effect of A. vera on fish health and immune responses. OBJECTIVES: In this study the effect of oral administration of A. vera on growth indices, hematological parameters and immune responses of rainbow trout were investigated. METHODS: One thousand five hundred rainbow trout fingerli...

Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Nowadays, the use of vaccines has been widely investigated for the prevention of different infectious diseases, infertility, immune disorders, malignancies, and allergies. Broad-spectrum adjuvant substances have been studied for immune system stimulation with a greater efficiency against specific antigens. V...

Immunol®(syrup) (0.65ml/kg), Gen-Xing®(tablet) (7.2mg/kg) and MufarrehYakuuti® (semi-solid) (87mg/kg) were administered orally at normal, 25% (0.82ml/kg, 9mg/kg 107.5mg/kg) 50% (0.98ml/kg, 10.8mg/kg 129mg/kg) increased dose to healthy male rabbits for two weeks. Non-specific Humoral immune responses measured throughpercent Neutrophil Adhesion assay Haemagglutination Antibody against Sheep RBCsr...