In the title compound, C(12)H(15)ClNO(+)·C(4)H(5)O(6) (-), the cyclo-hexa-none ring adopts a chair conformation. The benzene ring is significantly twisted so that it is in an almost perpendicular position to the C-N bond with a C(Ar)-C(Ar)-C-N torsion angle of -96.5 (5)°. Intermolecular N-H⋯O and O-H⋯O hydrogen bonds are observed in the crystal structure.

The recent manuscript in New England Journal of Medicine by Antonarakis et al. [1] has important clinical implications. This study evaluates mRNA expression of a particular androgen receptor splice variant-7 (AR-V7), in circulating tumor cells (CTCs) from metastatic castrate-resistant prostate cancer (mCRPC) patients receiving enzalutamide or abiraterone. The findings were striking, none of the...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 backgroun: little research has been carried out on whether the parental stress affects children's oral health in general and dental caries in particular. this study aimed to investigate the association between parental stress and early childhood caries (ecc). methods: a cross-sectional study was designed that included 250 ...

normal 0 false false false en-us x-none ar-sa radiation therapies are commonly used for malignant or metastatic brain tumors for curative and palliative use. the radiation-induced neurotoxicity includes both parenchymal and vascular damage. here we report the case of a 43-year-old woman who developed multiple sclerosis (ms) 9 months after she underwent the last session of radiotherapy for the d...