Tylophorine analogs exhibit a broad range of pharmacological activities, including anti-cancer, anti-inflammatory, anti-autoimmune, and anti-virus effects. Structure-activity relationship study of different structure tylophorine analogs can provide further understanding of their biological activity. Modifications on the E ring of the quinolizidine moiety of cryptopleurine analogs changed the po...

Protein kinase B (PKB/AKT) is an attractive therapeutic target in anticancer drug development. We have recently identified by docking-based virtual screening a low micromolar AKT-2 inhibitor. Additionally, the virtual screening hit represents a novel AKT-2 inhibitor scaffold. In this work, we discuss a structure-based design strategy toward the optimization of this hit. Following this strategy ...

The functions of intracellular signal transduction systems are determined by the temporal behavior of intracellular molecules and their interactions. Of the many dynamical properties of the system, the relationship between the dynamics of upstream molecules and downstream molecules is particularly important. A useful tool in understanding this relationship is a methodology to control the dynami...

Or Hen,1,* Bao-An Li,2 Wen-Jun Guo,2,3 L. B. Weinstein,4 and Eli Piasetzky1 1School of Physics and Astronomy, Tel Aviv University, Tel Aviv 69978, Israel 2Department of Physics and Astronomy, Texas A&M University–Commerce, Commerce, Texas 75429-3011, USA 3College of Science, University of Shanghai for Science and Technology, Shanghai, 200093, China 4Old Dominion University, Norfolk, Virginia 23...

Abstrakt. Information retrieval se mj. zabývá ukládáním a prohledáváním dokumentů. Vektorový model reprezentuje dokument jako vektor mnohorozměrného prostoru. Většina jeho implementací je bohužel efektivní jen pro malé dimenze, proto jsou hledány metody, jak dimenzi vektorů dokumentů snížit. V tomto článku ukazujeme jednu z možností – využití signatur (bitových řetězců pevné délky) které byly v...

1Division of Research, Peter MacCallum Cancer Centre, East Melbourne; 2Department of Medicine, St Vincent’s Hospital, University of Melbourne, Fitzroy; 3Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville; 4Department of Biochemistry and Molecular Biology, Monash University, Clayton; and 5Division of Haematology/Medical Oncology, Peter MacCallum Cancer Centre, S...