Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposom...

Copyright © 2010 Frederick Furness Publishing 14 Oral delivery continues to be the most popular route of administration due to its versatility, ease of administration and probably most importantly patient compliance. In a recent New England Healthcare Institute report, the cost of non-compliance in the US alone was estimated to be as much as $290 billion, or 13% of total annual health care expe...

The performance of regenerated cellulose (RC) films and capsules was investigated for their applications in oral controlled drug delivery. Regenerated cellulose films were prepared by non-solvent-mediated, phase inversion of native and depolymerized cotton linter solutions (methylolcellulose; cellulose dissolved in dimethyl sulfoxide/ paraformaldehyde solvent system) in water as well as by phas...

With an increasing number of lipophilic drugs under development, homolipids and heterolipids have gained renewed interests as excipients for oral drug delivery systems. Oral administration has many advantages for chronic drug therapy. It is relatively safe, convenient for the patient and allows self administration. This article is not intended to review the broad area of lipid-based vehicle for...

Nano drug delivery system is the latest technology employed in various medicinal applications. This technology can be adapted to the conventional drug administration due to its site-specific targeting phenomena. The oral lipophilic drug administration has its drawbacks due to poor solubility and bioavailability. Lipid-based carrier systems are now widely popular due to improved efficiency, espe...

Formulation, Fill & Finish 2003 10 he technologies behind oral drug delivery have emerged from the mainstream pharmaceutical industry and have become influential forces in their own right, as evidenced by the burgeoning “drug delivery companies” that are at the forefront of innovation and hold their own niche market. Drug delivery companies and their pharmaceutical industry partners are poised ...

INTRODUCTION Many therapeutics are limited to parenteral administration. Oral administration is a desirable alternative because of the convenience and increased compliance by patients, especially for chronic diseases that require frequent administration. Polymeric nanoparticles (NPs) are one technology being developed to enable clinically feasible oral delivery. AREAS COVERED This review disc...

The oral route is the preferred route for drug delivery, among oral delivery Intestine and colon drug delivery have been used for molecules aimed at local treatment of colonic diseases such as Colon Cancer, Polyp, Colorectal, Crohn’s Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC) etc. and for delivery of molecules susceptible to enzymatic degradation such as peptides. There ...