Probably the greatest challenge to those managing patients with oral diseases is the dilemma of attempting to predict which oral erythroplakias, leukoplakias, lichenoid and other potentially malignant mucosal disease (PMD) such as oral submucous fibrosis will progress to neoplasia--notably oral squamous cell carcinoma (OSCC). The paper reviews progress over the past decade and the application t...

An evaluation of the malignant potential of submucous fibrosis, based on observations of 89 patients with the disease in Ernakulam District, Kerala, India was done. Out of the 89 patients, 12 were referred patients and 77 were diagnosed in population based studies. At the time of first examination oral cancer was found to be coexistent in nine (10%) cases. For 66 patients follow-up observations...

This cross-sectional study was conducted to evaluate the prevalence of oral sub-mucous fibrosis among male school going children in a low socio-economic class and to analyze the relationship between oral submucous fibrosis and the use of various form of tobacco and areca nut. It was conducted on 54 male school going children aged between 10-19 years studying in classes VI to X of a public schoo...

Background: Nucleolar organizer regions (NORs) are defined as nucleolar components containing a set of argyrophilic proteins, which are selectively stained by silver methods. After silver-staining, the NORs can be easily identified as black dots exclusively localized throughout the nucleolar area and are called AgNORs. AgNORs have been used to assess biologic aggressiveness of lesions, such as ...

Verrucous carcinoma (VC) otherwise known Ackerman’s tumor is a distinct variety of epidermoid carcinoma with characteristic clinical presentation, behavior and histological features. It usually presents as a hyperplastic epithelium, abundant keratin superficially with a church-spire keratosis and also presenting parakeratin plugging which is characteristic of this VC. Oral squamous cell carcino...