Radiol Bras. 2015 Jul/Ago;48(4):VII–VIII The presence of bone metastasis is a relevant prognostic factor for cancer patients, and the skeleton is a common site of distant metastasis in cases of advanced-stage neoplasias. Recent developments in oncological treatments have led to a significant increase in patients’ survival. On the other hand, much of the morbidity and disability in such patients...

BACKGROUND Currently, serum biomarkers play an important role as sensitive tools for monitoring the cancer development and progression. Each biomarker represents a specific pathogenesis and has different predictive capability. In order to identify their characteristics in human osteosarcoma, multiple potential biomarkers were analyzed simultaneously with clinical presentations. MATERIALS AND ...

Alkaline phosphatase (ALP) flare phenomenon documented as scintigraphic flare phenomenon due to elevated serum ALP levels produced by osteoblasts reflects an osteoblastic reaction in response to the effective therapy of non-small cell lung cancer (NSCLC). Here, we report a case of ALP flare following gefitinib treatment for NSCLC. We also retrospectively analyzed the prevalence of ALP flare in ...

The bones are the most common sites of breast cancer metastasis. Upon arrival within the bone microenvironment, breast cancer cells coordinate the activities of stromal cells, resulting in an increase in osteoclast activity and bone matrix degradation. In late stages of bone metastasis, breast cancer cells induce apoptosis in osteoblasts, which further exacerbates bone loss. However, in early s...

AIM OF THE STUDY Different carcinomas have different characteristics, which may play a crucial role in diagnosis and treatment. Our study was aimed at understanding the development pattern of bone metastasis from hepatocellular carcinoma, based on its imaging characteristics, so as to provide a more targeted treatment. MATERIAL AND METHODS Forty two patients (123 lesions) with hepatocellular ...

objective: zoledronic acid as a main treatment for osteoporosis has an important role in differentiation of mesenchymal stem cells. however, mechanism of osteoblastic differentiation induction by zoledronic acid is not well understood until now. in this research we evaluate zoledronic acid effect on methylation status of runx2 and dlx5 promoters. materials and methods: after isolation and expa...

Bone metastatic cells release bone microenvironment proteins, such as the matricellular protein SPARC (secreted protein acidic and rich in cysteine), and share a cell signaling typical of the bone metabolism controlled by Runx2. The megakaryocytes in the bone marrow engrafted by the metastases seem to be one of the principal microenvironment sources of the biological stimuli, implicated in the ...