A 69-year-old man, with no remarkable medical history, had been working his entire life as a farmer in a rural area of Colombia. He presented with 3 months of fever, multiple cutaneous lesions, and 10 kg weight loss. Physical examination demonstrated that he was malnourished, pale, and had disseminated pustular skin lesions on the trunk and arms (Figure 1A and B). The remainder of the exam did ...

A 30-year-old man with no significant medical history, who had been working his entire life as a gold miner in rural Colombia, came to the infectious disease outpatient clinic at our institution with a two-month history of high spiking fevers, generalized lymphadenopathy (Figure 1), right lower quadrant pain, and vertigo. He did not report any weight loss or night sweats. He also reported heada...

Immunization with peptide P10, derived from gp43, and chemotherapy were used together in an attempt to improve treatment of paracoccidioidomycosis and prevent relapses. The combined treatment showed an additive protective effect when administered at 48 h or 30 days after intratracheal challenge. Its use is recommended to improve regular chemotherapy and reduce the duration of treatment.

Paracoccidioidomycosis is endemic in most countries of Latin America. Brazil has the greatest number of cases, with no autochthonous case registered in the state of Ceará. The cases of two patients that had never gone outside the State of Ceará and lived at least some years in the municipality of Palmácia.

BACKGROUND In previous studies, itraconazole was revealed to be an effective therapy and was considered to be the gold standard treatment for mild-to-moderate acute and chronic clinical forms of paracoccidioidomycosis. A pilot study was conducted to investigate the efficacy, safety, and tolerability of voriconazole for the long-term treatment of acute or chronic paracoccidioidomycosis, with itr...

Whole-body magnetic resonance imaging (MRI) is a diagnostic tool that enables the visualization of the entire body and combines fast acquisition times with high contrast resolution. An important advantage of this technique is the absence of ionizing radiation. Thus, whole-body MRI offers a radiation-free alternative to radionuclide imaging and CT for the diagnosis, staging, and monitoring of yo...