Peptide hormones labelled with radioactive iodine were partitioned into the aqueous two-phase polymer systems developed by Albertsson (1960) and the conditions required for separation of free from antibody-bound hormone have been worked out. Hormones studied included insulin, growth hormone, parathyroid hormone and [arginine]-vasopressin. Free and antibody-bound hormones show different distribu...

Bone turnover helps accomplish long-term correction of the extracellular calcium (Ca2+ o) homeostasis by the actions of osteoblasts and osteoclasts. These processes are highly regulated by the actions of hormones, most prominently parathyroid hormone (PTH), the release of which is a function of the Ca2+ o, and is regulated by the action of the Ca2+ -sensing receptor (CaR) in the parathyroid gla...

According to the World Health Organization (WHO) polycystic ovary syndrome (PCOS) occurs in 4-8% of women worldwide. The prevalence of PCOS in Indian adolescents is 12.2% according to the Indian Council of Medical Research (ICMR). The National Institute of Health has documented that it affects approximately 5 million women of reproductive age in the United States. Hormonal imbalance is the char...

Healthy term babies undergo a physiological nadir in serum calcium levels by 24-48 hours of age. The nadir may be related to the delayed response of parathyroid and calcitonin hormones in a newborn. This nadir may drop to hypocalcemic levels in high-risk neonates including infants of diabetic mothers, preterm infants and infants with perinatal asphyxia. The early onset hypocalcemia which presen...

Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, a...

Calcium is an essential ion within the human body. The maintenance of a constant free ionised calcium concentration is biologically important for the function of excitable tissues. Abnormalities in serum calcium values may have profound effects on neurological, gastrointestinal and renal function. Normal calcium concentrations are maintained as a result of tightly regulated ion transport by the...

Localization of 99mTc- hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) by parathyroid adenomas is well known, and this warrants MIBI scan to evaluate suspected parathyroid adenoma in primary hyperparathyroidism. Typically, the radionuclide concentrates in both the thyroid gland and parathyroid adenoma in early images, and later on delayed images washes out slowly from the...

introduction: the purpose of this study is to assess the integrated role of scintigraphy by tc99m mibi in diagnosis of parathyroid adenoma and its impacts on the myocardium, and to evaluate whether myocardium perfusion gated spect study could be a complementary routine workup for patient with positive parathyroid adenoma on tc99m mibi parathyroid scan. methods: rest myocardium perfusion gated s...

objective(s): in this study, we aimed to analyze the relationship between the diagnostic ability of fused single photon emission computed tomography/computed tomography (spect/ct) images in localization of parathyroid lesions and the size of adenomas or hyperplastic glands. methods: five patients with primary hyperparathyroidism (phpt) and 4 patients with secondary hyperparathyroidism (shpt) we...

Subcutaneous Parathyroid Hormone in ADH1 In this letter, the investigators report that continuous subcutaneous infusion of parathyroid hormone (1-34) six patients who were between ages 5 ...