Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease that manifests as acute relapses and progressive disability. As a primary endpoint for clinical trials in MS, disability is difficult to both characterize and measure. Furthermore, the recovery from relapses and the rate of disability vary considerably among patients. Given these challenges, investigators have devel...

OBJECTIVE Type 1 diabetes and multiple sclerosis (MS) are typical autoimmune diseases in children and young adults. We assessed the co-occurrence of type 1 diabetes and MS by estimating the relative risk (RR) for MS in a pediatric and adolescent diabetic population and looked for possible influencing factors. RESEARCH DESIGN AND METHODS Within the Diabetes Patienten Verlaufsdokumentation (DPV)-...

Multiple sclerosis (MS) is an inflammatory, demyelinating, neurodegenerative disorder of the central nervous system (CNS) of unknown etiology. The peak onset is between age 20 and 40 years and usually affects more women than men. Although much knowledge has been achieved on the diagnosis and treatment of adult patients with MS, it remains a matter of debate and controversy in childhood. We pres...

From the EMSC Panel (Writing Committee) on Critical Issues in the Sedation of Pediatric Patients in the Emergency Department: Sharon E. Mace, MD, Chair, American College of Emergency Physicians (ACEP) Lance A. Brown, MD, MPH (ACEP) Lisa Francis, BSN, RN (Society of Pediatric Nurses) Steven A. Godwin, MD (ACEP) Sigrid A. Hahn, MD (ACEP) Patricia Kunz Howard, PhD, RN, CEN (Emergency Nurses Associ...

From the Pediatric Palliative Care Program, Children’s Hospital of Wisconsin, Milwaukee (B.P.H., A.M.B.); the Department of Pediatrics, Division of Hematology–Oncology (B.P.H., A.M.B.), and the Department of Internal Medicine, Division of Neoplastic Diseases and Related Disorders (D.W.), Medical College of Wisconsin, Milwaukee; the Department of Pediatric Hematology– Oncology, Pediatric Palliat...

340. Household (HH) outbreak of ESBL-producing E. coli sequence type 131 (ST131) infection with high rate of ST131 intestinal colonization and extensive strain sharing among HH members Theresa Madigan, MD; James R. Johnson, MD; Connie Clabots, BS MT(ASCP); Brian D. Johnston, BA; Stephen B. Porter, MS; Billie S. Slater, MA; Ritu Banerjee, MD, PhD; Department of Pediatric and Adolescent Medicine,...