BACKGROUND A liquisolid technique has been reported to be a new approach to improve the release of poorly water-soluble drugs for oral administration. However, an apparent limitation of this technique is the formulation of a high dose because a large amount of liquid vehicle is needed, which finally results in a low-dose liquisolid formulation. Silica as an absorbent has been used extensively i...

Introduction: Repairing cartilage is an ongoing challenge due to the limited autonomous healing ability of cartilage, and the lack of long term intervention strategies. Therefore, there is a great need for engineered biomaterials for cartilage replacement therapy to delay further invasive treatments. Hydrogels have been explored for this purpose. Polyvinyl alcohol (PVA) hydrogels are one of the...

Effects of rifampin on in vitro oxidative metabolism and in vivo pharmacokinetics of diclofenac (DF), a prototypic CYP2C9 marker substrate, were investigated in rhesus monkeys. In monkey hepatocytes, rifampin markedly induced DF 4 -hydroxylase activity, with values for EC50 of 0.2 to 0.4 M and Emax of 2to 5-fold over control. However, pretreatment with rifampin did not alter the pharmacokinetic...

Effects of rifampin on in vitro oxidative metabolism and in vivo pharmacokinetics of diclofenac (DF), a prototypic CYP2C9 marker substrate, were investigated in rhesus monkeys. In monkey hepatocytes, rifampin markedly induced DF 4 -hydroxylase activity, with values for EC50 of 0.2 to 0.4 M and Emax of 2to 5-fold over control. However, pretreatment with rifampin did not alter the pharmacokinetic...

Effects of rifampin on in vitro oxidative metabolism and in vivo pharmacokinetics of diclofenac (DF), a prototypic CYP2C9 marker substrate, were investigated in rhesus monkeys. In monkey hepatocytes, rifampin markedly induced DF 4 -hydroxylase activity, with values for EC50 of 0.2 to 0.4 M and Emax of 2to 5-fold over control. However, pretreatment with rifampin did not alter the pharmacokinetic...

Effects of rifampin on in vitro oxidative metabolism and in vivo pharmacokinetics of diclofenac (DF), a prototypic CYP2C9 marker substrate, were investigated in rhesus monkeys. In monkey hepatocytes, rifampin markedly induced DF 4 -hydroxylase activity, with values for EC50 of 0.2 to 0.4 M and Emax of 2to 5-fold over control. However, pretreatment with rifampin did not alter the pharmacokinetic...

absorbed in the intestine mainly through the paracellular pathway. Their oral bioavailability is usually low since this pathway is severely restricted by the presence of the tight junctions. One of the possible strategies for solving this problem would be a controlled and reversible opening of the tight junctions, which could be achieved by compounds called paracellular permeability enhancers (...