Abstract Diffuse Intrinsic Pontine Glioma (DIPG) is a pediatric brain tumor characterized by epigenetic dysregulation with median survival of 9-11 months. Currently, radiation the only therapy option, and therefore calls for new, effective treatment method. RG2833 penetrant, selective HDAC 1/3 inhibitor. Western blot confirmed that alone downregulates NFkB pathway in multiple DIPG cell lines. W...
